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Alpha Emitters Market

Alpha Emitters Market Size, Share, Trends, Growth, Forecast Analysis, By Type of Radionuclide (Radium, Lead, Bismuth, Actinium), By Application (Bone Metastasis, Ovarian Cancer, Pancreatic Cancer, Melanoma, Lymphoma) & By Region - Global Market Insights 2022-2032

Alpha Emitters Market Outlook (2022-2032)

According to the alpha emitters market report by Fact.MR, a market research and competitive intelligence provider, the global market is valued at US$ 1 billion in 2022 and is expected to surge ahead at an astounding CAGR of 21% to reach US$ 6.7 billion by the end of 2032.

Based on application, alpha emitters are classified into bone metastasis, ovarian cancer, pancreatic cancer, melanoma, lymphoma, and others. Radium, lead, bismuth, and others are used in alpha emitters, which are useful in treatment procedures such as metastatic solid tumors (pancreatic cancer).

Demand for alpha emitters for use in ovarian cancer medical applications is predicted to rise rapidly at a CAGR of 22% from 2022 to 2032. This can be primarily attributed to the rise in ovarian cancer cases across the world.

A very important role is played by alpha emitters in the therapy of cancer. There are significant distinctions between this discipline of nuclear medicine and other fields due to the characteristics of alpha emitters. Alpha particles have been significantly taken into consideration in medical research due to their limited range and high LET (deposit energy in a unit length of their passage).

The subatomic particles known as alpha particles are made up of two neutrons and two protons. To restore balance, alpha particles are released when the nucleus of an atom gets unstable (the number of neutrons to protons is very low).

High atomic number elements such as radium, uranium, and thorium experience alpha decay. These elements' nuclei contain a lot of neutrons, which allows for the emission of alpha particles. Because alpha particles are sluggish and relatively heavy, they have little penetration strength and can be stopped by a piece of paper.

It is well known that alpha particles can significantly damage tumour cells. They directly harm the DNA of the cell in an irreparable way, which results in cell death.

However, the alpha particle's range of motion in tissue is relatively constrained. Consequently, using alpha particles as a locally delivered therapy for solid tumours was not possible until now.

?To get over the short-range restriction of alpha particles, the Alpha DaRTTM technology uses the diffusion of atoms that emit alpha particles into the tumour tissue. The extensive region that alpha radiation may cover makes it possible to potentially treat the entire tumour.

The Alpha DaRT method relies on tiny, incredibly precise doses of radioactive radium-224 attached to metal sources placed inside the tumour. The short-lived radioactive atoms are released when radium-224 decays and disseminate throughout the tumour. These atoms produce short-range alpha radiation, which quickly damages and kills cancerous cells.

Alpha DaRT has special qualities that may considerably improve the effectiveness, safety, and ease of cancer treatment, including higher linear energy transfer, irreversible break of both DNA, potential utility in all solid tumour types, minimal capital funding, ultra-minimally invasive application, and more.

The substantial and sophisticated research and development efforts being carried out in the field of cancer therapy are the main factors driving the growth of the alpha emitters market. This is related to the emerging understanding of targeted alpha emitters' capacity to kill cells.

In accordance with this, the market is being stimulated by the increasing frequency of different types of cancer among the populace. Additionally, a bright market for alpha emitters is being created by the growing senior population, which is sensitive to several cardiac and cancer disorders.

Furthermore, increased use of targeted anticancer or alpha therapy (TAT) in healthcare institutions is generating more opportunities in the alpha emitters market.

Report Attributes

Details

Alpha Emitters Market Size (2022E)

US$ 1 Billion

Forecasted Market Value (2032F)

US$ 6.7 Billion

Global Market Growth Rate (2022-2032)

21% CAGR

China Market Growth Rate (2022-2032)

20% CAGR

Key Companies Profiled

  • Actinium Pharmaceuticals, Inc.
  • Alpha Tau Medical
  • Bayer AG
  • Fusion Pharma
  • IBA Group
  • IBA Radiopharma Solutions
  • Lantheus Medical Imaging, Inc.
  • NTP Radiosotopes SOC Ltd.
  • RadioMedix, Inc.
  • Siemens Healthineers
  • Telix Pharmaceuticals Ltd.
  • Triad Isotopes, Inc.

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Why are Sales of Alpha Emitters Rising So Rapidly?

“Large Population Living with Various Forms of Cancer”

Demand for alpha emitters is projected to rise as a result of rising consumer knowledge of the targeted alpha emitter's potential advantages and a large patient population suffering from various malignancies, including ovarian, pancreatic, lymphoma, melanoma, and others.

Furthermore, the application of targeted anticancer or alpha therapy in the treatment of cancer is expanding, as alpha particles have significance in targeted therapy due to their extraordinarily high capacity to kill cells.

  • For instance, the International Agency for Research on Cancer (IARC) projects that by 2040, there would be 16.3 million cancer deaths and 27.5 million cancer occurrences worldwide, mostly as a result of senior population growth. In low- and middle-income nations, cancer deaths account for about 70% of all fatalities.

As a result, it is anticipated that there would be a rise in the need for radiopharmaceuticals to treat cardiovascular and cancer-related disorders.

As more chronic diseases are being treated with alpha-targeted therapies, key manufacturers in the alpha emitters market are becoming more aware of their potential benefits. Short-range, high-efficiency α-particle radioimmunotherapy is an innovative and promising therapeutic strategy. Targeted therapy benefits from the very high cell-killing capacity of α-particles.

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What Should Manufacturers of Alpha Emitters Be Aware Of?

“Strict Regulatory Policies to Hamper Sales of Alpha Emitters”

Clinical research and translational studies are hampered by regulatory rules. For example, the FDA in the United States regulates all pharmacologic agents, including diagnostic radiopharmaceuticals and radiotherapies.

Similar to this, radiopharmaceuticals go through particular regulatory and approval processes worldwide and are subject to increased scrutiny. This may hinder the sales growth of alpha emitters.

Alpha emitters market forecast by Fact.MR

Know thy Competitors

Competitive landscape highlights only certain players
Complete list available upon request

Which Region is Expected to Lead Global Sales of Alpha Emitters?

“Rising Cases of Cardiological & Cancerous Disorders in North America”

Currently, North America dominates the global alpha emitters market and it is anticipated that this dominance will continue throughout the forecast period as well due to the rising cardiological and cancerous disorders in the region.

  • For instance, a trial including ten patients with malignant skin and soft tissue tumours revealed that the Alpha DaRT, diffusing alpha-emitter radiation therapy, produced complete responses (CRs) in accordance with RECIST v1.1 criteria.
  • In the United States, Alpha Tau Medical Ltd. began a multi-center pivotal trial for skin cancer in 2022.

Cancer is the second-largest cause of death and morbidity in Europe. This creates wide opportunities for the manufacturers of alpha emitters during the forecast period.

Rise in the adoption of innovative products and an increase in the prevalence of cancer in developing countries such as China, Japan, and India are expected to fuel the sales growth of the Asia Pacific market.

Country-wise Analysis

What Makes the U.S. a Leading Market for Alpha Emitters in North America?

“Rising Cases of Cancer Augmenting Sales of Alpha Emitters”

One of the most common causes of chronic illness in the United States is cancer.

  • According to projections by the American Cancer Society, the United States would experience 1.9 million fresh cancer cases and 609,360 cancer-related fatalities in 2022.

The oncology market in the United States is expanding, which is fueling the demand for alpha emitters. This number is anticipated to rise significantly in the coming years.

How is Demand for Alpha Emitters Progressing in European Countries?

“High Demand from Nuclear Medicine & Radiopharmaceutical Applications”

As there is high demand for alpha emitters from nuclear medicine and radiopharmaceutical applications, Germany holds an impressive share in the Europe alpha emitters market, followed by France, Italy, the United Kingdom, and Spain.

Due to the presence of numerous large and small businesses with comparable product offerings, the market for alpha emitters in European countries is very competitive. To raise their market shares and gain a firm presence in the European market, these organisations employ a variety of tactics such as agreements, acquisitions, market developments, website launches, marketing and promotional activities, and technological advancements.

Category-wise Analysis

Why is Demand for Alpha Emitters High for Ovarian Cancer Treatment?

“Ovarian Cancer Leading to High Number of Deaths”

  • Ovarian cancer is the fifth most prevalent cancer-related cause of death among women in the United States, according to the American Cancer Society. The American Cancer Society predicts that 19,880 women will be newly diagnosed with ovarian cancer in the U.S. in 2022. Ovarian cancer will claim the lives of approximately 12,810 women.

The main market participants are concentrating on creating cutting-edge radionuclides for the treatment of various forms of ovarian cancer.

For example,

  • January 2021: Soricimed Biopharma Inc. and Orano Med decided to concentrate on the creation of an advancedPeptide Receptor Radionuclide Therapy to treat solid tumour cancers.

The businesses are examining the potential of this cutting-edge strategy for the treatment of cancer using Soricimed's TRPV6 cancer receptor-targeting peptides and Orano Med's special radioactive alpha emitter, lead-212 (212Pb).

Radioimmunotherapy is used as a locally administered adjuvant therapy for ovarian cancer. Trials have examined the use of non-specific IP radiation, moving-strip EBRT, or total abdominal EBRT with colloid preparations of Au-198 or P-32 as adjuvant treatments.

Targeted alpha therapy using shorter wavelengths and higher LET has shown promise in the therapeutic process. Projection forecasts indicate that this trend will continue to expand in the coming years.

Competitive Landscape

There are only a few significant companies in this less-competitive alpha emitters sector.

Actinium Pharmaceuticals, Inc., Alpha Tau Medical, Bayer AG, Fusion Pharma, Lantheus Medical Imaging, Inc., NTP Radiosotopes SOC Ltd., RadioMedix, Inc., Siemens Healthineers, and Triad Isotopes, Inc. are some of the key players in the alpha emitters market.

  • A formal business merger agreement was signed by Healthcare Capital Corp. and Alpha Tau Medical Limited in July 2021. This deal is used to further Alpha Tau's clinical plan, which includes pursuing FDA marketing permission, engaging in a wide range of R&D initiatives, increasing manufacturing capability, and getting ready for commercialization.

Key Segments in Alpha Emitters Industry Research

  • By Type of Radionuclide:

    • Radium
    • Lead
    • Bismuth
    • Actinium
  • By Application:

    • Bone Metastasis
    • Ovarian Cancer
    • Pancreatic Cancer
    • Melanoma
    • Lymphoma
  • By Region:

    • North America
    • Latin America
    • Europe
    • East Asia
    • South Asia & Oceania
    • MEA

- Premium Report Details -

Alpha Emitters Market
  • FACT7810MR
  • Oct-2022
  • Healthcare
  • 170 Pages
  • 25 Tables
  • 132 Figures

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Global sales of alpha emitters are expected to surge at a CAGR of 21% from 2022 to 2032.

The global alpha emitters market currently accounts for a valuation of US$ 1 billion.

Worldwide demand for alpha emitters is projected to reach US$ 6.7 billion by 2032.

Demand for alpha emitters in China is expected to expand at a high CAGR of 20% from 2022 to 2032.

Actinium Pharmaceuticals, Inc., Alpha Tau Medical, Bayer AG, Fusion Pharma, Lantheus Medical Imaging, IncRadioMedix, Inc., Siemens Healthineers, and Triad Isotopes, Inc. are some of the key players in the alpha emitters market.

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