Pepsin Market

Pepsin Market Outlook Global Insights 2023 to 2033

The global pepsin market is highly affected by the rising emergence of gastrointestinal diseases, especially in the geriatric generation, says Fact.MR. The market’s estimated valuation is US$ 49.9 million in 2023.

The surging use of pepsin across the pharmaceutical sector will create lucrative opportunities for market growth. For the drug development of gastrointestinal diseases, many times pepsin is the key ingredient. Further, it has a huge demand for pharmaceutical R&D, as it is used as a major tool for FAB fragmentation, which is an essential part of the drug trial.

Report Attributes	Details
Estimated Market Value (2023E)	US$ 49.9 Million
Forecasted Market Value (2033F)	US$ 70.5 Million
Global Market Growth Rate (2023-2033)	~3.5% CAGR
North America Market Share (2023)	~29.0%
North America Market Growth Rate (2023-2033)	~4.2% CAGR
US Market Growth Rate (2023-2033)	~4.3% CAGR
US Market Share (2023)	~89.5%
Key Companies Profiled	A. Constantino & C. Biolaxi Corporation BIOZYM Chongqing quanxinxiangsheng Chongqing Jingkang Biotechnology Deyang Sinozyme Enzymology Research Center Limited

Historic and Future Path for Pepsin Market

Pepsin, a powerful stomach enzyme in gastric juices digests proteins found in ingested food such as meat, seeds, and dairy products. Pepsin is an endopeptidase and the principal acid protease of the stomach. Pepsin is even named Pepsin A, Pepsin B, and Pepsin C (gastricsin). Pepsin preferentially hydrolyzes peptide linkages, wherein one amino acid is aromatic accounting for nearly 20% of protein digestion, and also has an optimal function with a pH of 1.5-2.0 and becoming inactive at higher pH. A low pH activates pepsin.

• Growth Factors for Short Term (2023-2026): The growth witnessed by the enzyme market is due to the rising application from various end-use sectors. Further, the advancements in technology and enzyme engineering is propelling the market's growth. In addition, the depletion of non-renewable resources has increased public concern over the environment and highlighted the significance of producing biofuels. Additionally, the growing contribution and adoption of key strategies by major market players will fuel the market's growth.
• Factors for Medium-Term Growth (2026-2029): The market in North America is burgeoning due to the presence of a plethora of industrial and pharmaceutical applications for the pepsin market. Pepsin is an enzyme and requires an acidic medium to be active, in such cases drug trials or approval by the FDA is mandatory, and the imposition of stringent regulations is likely to impact the use of pepsin across industries and ultimately affect the application areas of pepsin across industries.
• Long Term Growth Opportunities (2029-2033): Leading market players are adopting various ground-breaking strategies and investing in advancing technologies to launch animal-free pepsin and are focusing on enhancing their capacity and improving customer portfolios. Hence, enhancing and expanding the distributor portfolio, coupled with capacity building for production, are major strategies adopted by key players set to drive market in a long run.

According to Fact.MR, the historical period from 2018 to 2022 saw a 2.5% growth rate for the global pepsin market and it is estimated that during the projection period of 2023–2033, the market is set to grow at a 3.5% CAGR.

Market Dynamics Overview

“Treatment of Hides for Leather Propels Market Growth”

Leather has a huge adoption rate across various industries such as fashion, automotive (seats), and others. Leather has been a significant part of the fashion industry. Various multinational brands use leather to lure their elite-class customers and gain traction. In addition, plant-based leather has also penetrated the market due to its unique offerings coupled with the veganism trend.

However, on leather, the undesired traces of hair, tissues, and other unwanted components are attached, and in order to remove them, the pepsin enzyme is used as it breaks down the protein. Such enzymatic treatment is known as bating, and the process softens or de-swells the hide, enhancing the quality of the leather.

Thus, the treatment of leather with pepsin enzymes removes the unwanted and provides quality leather for further use. Hence, the constant demand for leather products will increase the need for pepsin enzymes for the treatment of hides. This will propel revenue growth.

“Multiple Functions in Food Production to Ensure Long-term Growth”

Pepsin has various applications in the food and beverage sector, which boosts the market's growth. The pepsin enzyme acts as an integral component of pancreatic curd that condenses and twists during the production of cheese for various applications. Cheese has high demand. The use of cheese over fast foods to improve their taste has an immensely positive impact on the sales of such food. Hence, the demand for cheese is amplified. To meet the requirement, cheese manufacturers use pepsin as it is economical and easy to avail. Pepsin has replaced rennet in cheese manufacturing.

Furthermore, pepsin is utilized for the modification of gelatin and soybean protein for further use. In addition, it helps to achieve a whipping texture. Pepsin also improves the protein content of non-dairy products. Such foods have high demand in both developed and developing nations as they are easy to cook and consume. The pepsin enzyme has many applications in the preparation of plant and animal protein, after which the protein is hydrolyzed and used for the flavoring of beverages and food products.

“Lack of Standardization and Associated Side-effects of Over-consumption of Pepsin”

Local brands or SMEs lags in infrastructure and standardization. The lack of standardization in drug preparation leads to formulation errors or high pepsin dosage, which further leads to various disorders. Pepsin is an essential enzyme for the digestion of food and other applications. However, the overconsumption of pepsin may result in various health issues, which may be fatal if not treated on time.

For instance, the over-consumption of pepsin or the over-secretion of pepsin can result in mucosal tissue damage in the gastrointestinal tract, along with indigestion, nausea, abdominal pain, and diarrhea, among others. Such incidences may develop a negative perception among potential customers and result in declining demand.

Based on early diagnosis, the management of ulcers and the dissolution of the mucosal lining can be managed. However, in the wake of a failure to do that, the mucosal lining gets thin and results in painful ulcers. This, in turn, negatively affects the market's growth

Country-wise Insights

Why the US is Anticipated to Dominate Pepsin Consumption?

The modern-day population, especially the geriatric population, is more prone to gastrointestinal problems. This is increasing the demand for effective medication to enhance the quality of life. Here, the pepsin enzyme and related medication come into play. For instance, as per data from the United Nations, it is estimated that by 2050, one in every six people at the global level will be over 65 years of age, i.e., 16.0%. It is an increase from one in 11 in 2019, i.e., 9.0%. Hence, the U.S. pepsin market is estimated to grow at a CAGR of 4.3% during the forecast period.

How does China Play a role in the Expansion of the Pepsin Market?

The growing demand from emerging economies, especially from China and India, coupled with increasing healthcare infrastructure and biotechnology investments.

For instance, China intends to build 10 to 20 biomedicine and life-science parks with a combined output exceeding USD 1.5 billion by 2020, according to data from the American Chemical Society (CAS). Additionally, 100 life-science parks have already been built across the nation, and the government has allocated USD 100.0 billion to investments in innovation. These in turn help to increase pepsin demand.

Category-wise Insights

Why is Pepsin Demand Increased by Pharma Grade?

The growing investments in pharmaceuticals and biotechnology will boost the pepsin market growth. For use in biological research, medical research, and other practical applications where it is necessary or desired, pepsin is used to cleave antibodies into functional antigen-binding fragments (FABS).

The market of pepsin in the pharmaceutical industry is expected to grow at a CAGR of 3.8%.

Will Market Growth Be Led By Animal-Free Pepsin Products?

People across the globe are now demanding vegan health supplements that are free from any ingredients derived/sourced from animals. Plant-based dairy and meat sales were over US$ 32 billion in 2022 and are expected to reach US$ 165 billion by end of 2032.

This shows the growing interest of people in vegan supplements. In the pepsin market, Clara Foods launched its first animal-free pepsin, which could aid the development of medicines and food products that are vegan and animal free. Such strategies and initiatives by the market player will fuel the market's growth.

Market Players’ Key Strategies

Prominent pepsin manufacturers are A. Constantino and C. spa, American Laboratories, Antozyme Biotech Pvt. Ltd., and Every Company (Formerly Clara Foods).

Leading market players are adopting various ground-breaking strategies and investing in advancing technologies to launch animal-free pepsin and are focusing on enhancing their capacity and improving customer portfolios. Hence, enhancing and expanding the distributor portfolio, coupled with capacity building for production, are major strategies adopted by key players.

Fact.MR has provided detailed information about the price points of key manufacturers of pepsin positioned across regions, sales growth, production capacity, and speculative technological expansion, in the recently published report.

Segmentation of Pepsin Industry Research

• By Source :

  • Animal Free
  • Animal Based

• By Grade :

  • Pharma Grade
  • Biochemical Reagent Grade
  • Food Grade

• By Form :

  • Powder
  • Liquid

• By Application :

  • Bating (Leather Finishing)
  • Food & Beverages
    • Gelatin Modification
    • Soybean Protein Modification
    • Modified Plant Protein
    • Chewing Gum Production
    • Cheese Curdling
    • Others
  • Pharmaceuticals
    • Gastrointestinal medications
    • Biomedical research
    • Others
  • Others

• By Region :

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia & Oceania
  • MEA