Keratoprosthesis Market

Keratoprosthesis Market Outlook (2024 to 2034)

Revenue from the global keratoprosthesis market is estimated to reach US$ 553.5 million in 2024. The market is analyzed to rise at a high-value CAGR of 15.4% to reach US$ 2.33 billion by the end of 2034.

The primary factor driving the market for keratoprosthesis is the increasing incidences of eye conditions. One significant market driver is the rise in the prevalence of conditions associated with the eyes, such as infectious keratitis, corneal stromal dystrophies, ocular cicatricial pemphigoid, and keratoconus. Based on research, the prevalence of keratoconus is estimated to be between 50 and 200 per 100,000 people. The prevalence in the United States is at 54.5 per 100,000 people.

The synthetic sector is estimated to hold a significant revenue share as synthetic artificial corneal implants are more common than biosynthetic ones in the market, which has increased acceptance rates. Additionally, more businesses are focusing on creating synthetic artificial corneal implants. For example, CorNeat Kpro is a synthetic cornea that offers a long-term medical cure for corneal blindness, disease, and injury. It is now undergoing clinical testing and is anticipated to launch in 2023.

Given the increased use of these products-particularly Boston Kpro-the hard keratoprosthesis sector is now holding a leading market share. This artificial cornea is the most popular one, and its use has increased exponentially in recent years than ever before due to improved outcomes and ongoing design advancements as well as better postoperative care. Over 11,000 Boston Kpro implantations have been performed to date by 598 surgeons in 66 countries, according to a research paper released in 2022 by the Harvard Medical School's Department of Ophthalmology.

Report Attribute	Detail
Keratoprosthesis Market Size (2024E)	US$ 553.5 Million
Forecasted Market Value (2034F)	US$ 2.33 Billion
Global Market Growth Rate (2024 to 2034)	15.4% CAGR
East Asia Market Share (2024E)	18.3%
North America Growth Rate (2024 to 2034)	18.2% CAGR
Demand from Hospitals (2024E)	US$ 365.2 Million
Key Companies Profiled	F. Hoffmann-La Roche Ltd.; Regeneron Pharmaceuticals Inc.; Pfizer Inc.; Bayer AG; Bausch & Lomb Incorporated; AJL Ophthalmic; CorneaGen Inc.; Addition Technology, Inc.; LinkoCare Life Sciences AB; Presbia plc; Mediphacos; Aurolab; Cornea Biosciences; DIOPTEX GmbH; EyeYon Medical; Massachusetts Eye and Ear; Florida Lions Eye Bank; SightLife; Advancing Sight Network; San Diego Eye Bank; L V Prasad Eye Institute.

Keratoprosthesis Market Outlook (2024 to 2034)

The keratoprosthesis market is expected to grow exponentially over the forecast period due to the increasing incidence of corneal infection. Increasing visual disability due to the cloudy cornea for working people has increased the demand for keratoprosthesis surgeries. Based on product types, the global keratoprosthesis market is segmented into Boston Keratoprosthesis, alphaCor, and others. Amongst them, Boston Keratoprosthesis is the most widely used treatment option for corneal disease.

The exponential rise in the use of medical devices on account of continued advances in design and superior operative care has led to an increase in the use of artificial cornea or keratoprosthesis in recent years. Keratoprosthesis surgical procedure replaces the section of the cornea along with being placed in the surrounding tissue. A variety of biological materials are being considered for improving prosthetic corneal implants.

Demand Impetus of the Keratoprosthesis Market

Corneal transplantation is one of the widely adopted treatments to correct opacities in the cornea. This process involves the use of tissue from a human donor. The failure in cornea treatment sometimes results in the development of keratoprosthesis, which is used when corneal transplantation is not an option. The lack of human donors for the cornea is another factor that affects positively the demand for the keratoprosthesis market.

Governments in developing economies are heavily investing in healthcare infrastructure. This is likely to witness significant growth in keratoprosthesis demand in the forecast period. Increasing incidences of corneal blindness along with patients who have failed human corneal transplantation may create potential growth prospects for the keratoprosthesis market.

As per the United States eye banks data published in EBAA, there were around 126,623 total tissue recoveries in 2021. These recoveries involved about 64,048 donors. In 2021, total donors saw growth of 14.5%, and total corneas donated were up 16.8% compared to 2020. These facts signify the potentiality of continuous growth in the keratoprosthesis market share in the forecast period.

The rising number of skilled medical practitioners and increased standards of eye care services are expected to be important factors driving the keratoprosthesis market. Further, improvement in designs and effectiveness of the device will possibly guide the assessment period of the keratoprosthesis market.

Deterrents for the growth of the Keratoprosthesis Market

The major restraint faced by this market is the lack of human donors for cornea replacement expected to take the demand trajectory upward in the forecast duration. The lack of awareness of this surgery is potentially affecting the expansion of the market size in keratoprosthesis in the forecast period.

The researchers need high costs as well as there, are costs owned by the vendors for regulatory compliance which is triggering prices of final surgery for patients. However, with rising insurance coverage, improved penetration of Medicare is projected to reduce the financial burden on the patients.

Segment wise analysis

Biosynthetic implants are expected to have the largest share of the keratoprosthesis market.

Based on the types of implants used in keratoprosthesis the market is segmented into, synthetic and biosynthetic implants. Biosynthetic implants are widely used for their safety and lower manufacturing costs. These benefits are likely to drive the demand for biosynthetic implants over conventional synthetic implants in the assessment period. The hospital segment in the end-user industry is expected to record a 66% share in 2024.

Based on end users, the keratoprosthesis market is led by the hospital segment owing to the rise in eye special clinics. Considering the complications and higher precision required in keratoprosthesis people and doctors prefer hospital setups over ambulatories. The presence of skilled staff, high-precision equipment, and transactional eye banks available under one roof is a major factor driving growth for this segment.

Regional analysis

North America is expected to dominate the keratoprosthesis market in terms of revenue share followed by Western Europe. Germany leads the markets in Europe owing to rising healthcare investment and research. The opt-out system for donating an organ is present in the USA, which is leading to the promotion of corneal donations thereby expecting further growth in markets.

The Asia Pacific is expected to experience delayed growth due to the lack of skilled physicians. However, Asia Pacific is expected to be the most lucrative market for keratoprosthesis with maximum CAGR due to the growing penetration rate of keratoprosthesis surgeries in emerging markets.

Moreover, an increasing number of healthcare practitioners and continuous improvements in the healthcare infrastructure are expected to enable robust industry growth in the APAC region. Countries such as China and India are expected to emerge as the leading region in the forecast period owing to the high population.

The Middle East and Africa are expected to witness slow and significant growth over the forecast period. Lesser penetration of technical advancement in the region is responsible for the delay in growth in the keratoprosthesis market.

Recent developments

The present developments in keratoprosthesis aim to enhance the integration of implant tissue with the host tissue. The anatomical results are aimed at using biocompatible materials. The long-term and sustainable vision is targeted by the researchers. The companies are giving prime consideration to post-operative complications such as glaucoma, extrusion, and infection. The newer materials should be targeted by the researchers for excellent optical properties.

Corneat Vision in 2022 proclaimed that CorNeat Kpro is under trial by the firm which is expected to arrive in 2024. Collagen-based bioengineered corneas have recently been introduced into the market and are becoming popular owing to their lower cost and compatibility in implantation.

This process ensures safety and effectiveness in surgery. The manufacturers in the keratoprosthesis market are increasingly focusing on the development of new techniques and products. The artificial cornea industry is marked by dominant players’ competition and product differentiation.

Segmentation of the Keratoprosthesis Market Research

• By Implant Type :

  • Synthetic
  • Bio-Synthetic
  • Others

• By Disease Indication :

  • Bullous Keratopathy
  • Keratoconus
  • Keratitis
  • Others

• By End Users :

  • Hospitals
  • Ambulatory Surgical Centers
  • Others

• By Region :

  • North America
  • Easter Europe
  • Western Europe
  • East Asia
  • Latin America
  • South Asia & Pacific
  • Eastern Europe
  • Middle East & Africa