Cas9 nuclease is CRISPR associated protein 9 is a bacterial immune defence nuclease protein which functions with Repetitive DNA sequences CRISPR. It is heavily utilized in genetic engineering applications to cleave target DNA to remove undesirable segments or introduce desirable genes at target sites. Cas9 nuclease is found as eSpCas9 and SpCas9-HF with improved target editing activities, independent of two sgRNAs. The advancing research is deliberated to develop novel anti-CRISPR proteins with improved accuracy. Cas9 nuclease has a vast patent landscape and complex licensing domain of Cas9 nuclease by leading research institutes, universities and companies. Coronavirus pandemic has jolted globe with the massive infections spread and fatalities. Coronavirus has pushed the global Cas9 nuclease market with escalated research and studies. Several companies have tested Cas9 nuclease for Coronavirus diagnostics such as Sherlock Bioscience, Mesa Biotech’s Accula device with FDA authorization and others. The ongoing research is expected to leverage the novel diagnosis and treatment for Coronavirus with speed and efficacy at mass level.
Cas9 Nuclease Market: Drivers and Restraints
The global Cas9 nuclease market is driven by its massive research application into agriculture, industrial and animal biotechnology, novel enzymes, therapeutics and medical-research for cancer, hemophilia, viral/bacterial pathogenesis cancers, HIV, diabetes etc. Cas9 nuclease has also leveraged the agricultural developments, such superior quality and trait crops, diseases and stress-resistance in apple, rice, lettuce, grapevine and tobacco with DNA-free Cas9 nuclease. The advancing R&D, global healthcare expenditure, surging diseases, personalized treatment, government investments, key players, startups, emerging companies’ products with massive licensing and intellectual-property portfolio are fuelling the Cas9 nuclease market. However, the high-cost of Cas9 nuclease, lack of awareness and ill-use of Cas9 nuclease, ethical issues and the dearth of skilled researchers in developing or under-developed countries decelerates the Cas9 nuclease market growth. Although, the overall global Cas9 nuclease market growth is expected to escalate with the progressing research, approvals and acceptance of Cas9 nuclease products, patents and licensing activities, leading and emerging companies.
Cas9 Nuclease Market: Segmentation
The global Cas9 nuclease market is segmented into products, applications, end-users and regions.
By products, the global Cas9 nuclease market is further segmented into:
- Vector Based
By application, the global Cas9 nuclease market is further segmented into:
- Genome Engineering
- Disease Models
- Functional Genomics
By end-users, the global Cas9 nuclease market is further segmented into:
- Research Institutes
- Company R&D
- Contract Research Organizations (CROs)
Cas9 Nuclease Market: Overview
The global Cas9 nuclease market is anticipated to leverage with the holistic applications in various biotechnology industries and research. By product, vector-based Cas9 nuclease dominates the market due to wide-range research applications with background expressions into cell lines, drug testing and genome modifications, gene targeting and delivery. By application, genome engineering leads the Cas9 nuclease application due to the perse genetic alteration researches with Cas9 nuclease for the deletion of lethal and addiction of desirable genes, DNA modification, immunology-focused studies, human disease models and novel Cas9 nuclease based therapy development for various chronic diseases and infections. By end-users, research institutes dominate the Cas9 nuclease market with the massive and advancing research activities, investments and patents. Research institute bags 60% of patents in Cas9 nuclease domain, with major attribution by research institutes of U.S. and China.
Cas9 Nuclease Market: Regional Outlook
North America dominates the global Cas9 nuclease market with major attributions from the advanced research, technology and biotechnology industry with the holistic applications of cas9 nuclease, giant IP profiles of key players, government’s investment, highest R&D expenditures, perse product and services. Europe holds the second largest global Cas9 nuclease market with its advanced research and technology, escalating biotechnology industry and acceptance of Cas9 nuclease products and uses into agriculture, genetics and medicine. Asia-pacific Cas9 nuclease market is growing with significant pace, driven by the progressing Asian therapeutics research, clinical trials of the Cas9 nuclease products, in vivo applications and gene editing 9 into medical and agriculture biotechnology. China holds numerous patents in this technology domain which further propels the regional market. Latin America Cas9 nuclease market is supported by the progressing Biotechnology R&D and industries, rapid sequencing and genetic modifications and drug discoveries. Mea &Africa Cas9 nuclease market is growing gradually due to the high cost associated with Cas9 nuclease technology and the dearth of skilled professionals.
Cas9 Nuclease Market: Key Players
The key players of global Cas9 nuclease market include CRISPR Therapeutics, AstraZeneca, Roche, New England BioLabs, Lonza, Addgene, Caribou Biosciences, Cellectis, Novartis, Bayer, eGenesis, Editas Medicine, Thermo Fisher Scientific, Sigma-Aldrich, Agilent Technologies, Evolva and others.
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