Melatonin API Market

Melatonin API Market Outlook (2024 to 2034)

The melatonin API market size is estimated to be valued at US$ 2,371.9 million in 2024. Projections indicate an expansion with a remarkable CAGR of 18.0% through the year 2034. Anticipated growth is set to propel the market to an impressive size of US$ 12,450.2 million by 2034. Increasing awareness of the role of melatonin in sleep regulation is fueling the market's growth.

The last few years have seen a tremendous rise in the demand for sleep-inducing supplements, especially in the younger demographic. This has pushed pharmaceutical companies to innovate and introduce new products, such as those containing melatonin API, to cater to this growing market. The consumer demand for melatonin API is also surging because of its perceived natural and holistic approach to sleep management.

Melatonin API finds its applications in various industries, such as pharmaceuticals, nutraceuticals, and cosmetics, due to its versatile properties. In the nutraceuticals industry, melatonin API is utilized to formulate dietary supplements designed to support various aspects of health and wellness. Its demand in the cosmetic industry is also skyrocketing as melatonin API offers antioxidant properties.

The melatonin API market generated an estimated revenue of US$ 1,136.6 million in 2019. In five years, the market grew at a pace of 15.85% and added a revenue of US$ 1,235.3 million.

Report Attributes	Details
Estimated Market Value (2024E)	US$ 2,371.9 million
Forecasted Market Value (2034F)	US$ 12,450.2 million
Global Market Growth Rate (2024 to 2034)	18.0% CAGR
GMP Segment Growth Rate (2024 to 2034)	92.50%
Clinical Use Segment Growth Rate (2024 to 2034)	83.40%
North America Market Share (2024)	43.80%
East Asia Market Share (2024)	18.00%
Key Companies Profiled	Merck KGaA Caesar & Loretz GmbH EVONIK Bio-Techne Corp. Cayman Chemical Company (Matreya) Spectrum Chemical Caesar & Loretz GmbH LGM Pharma Flavine Europe GmbH Ralington Pharma LLP Simson Pharma Limited Santa Cruz Biotechnology, Inc. Biosynth Otto Chemie Pvt. Ltd. Pharmaffiliates Analytics and Synthetics P. Ltd. Clearsynth Labs

Which Factors Have Driven the Global Surge in Melatonin API Demand?

“Rising Sleep Disorders and Nutraceutical Trends Driving the Demand for Melatonin API”

According to a recent study conducted by the American Sleep Association, more than thirty percent of adults get less than six hours of sleep each night. This has led to rising incidences of sleep disorders in the general population, significantly increasing the demand for melatonin API in the pharma and healthcare industry as it helps regulate sleep cycles and improve overall sleep quality.

Besides this, there also has been a considerable push toward nutraceuticals, with a focus on natural and alternative health solutions. Melatonin API, being a natural hormone, is a perfect choice for individuals seeking effective health solutions for sleep-related issues. Their demand from the public at large is also skyrocketing due to the active promotional initiatives by fitness gurus, healthcare experts, and nutritionists on various social media sites.

“Growing Awareness and Lifestyle Changes to Boost Market Growth”

The demand for melatonin APIs in the advanced medical industry is also touching the skies due to the growing awareness of melatonin's role in regulating sleep cycles and overall well-being. This has spurred consumer interest in incorporating melatonin APIs as a key component in advanced medical formulations. Melatonin API is also gaining popularity in the pharma industry due to its potential broader health benefits.

Modern lifestyle factors, including stress and irregular sleep patterns, along with a sedentary lifestyle and over-consumption of alcohol and caffeinated products, have led individuals to seek melatonin supplements. This has significantly boosted the market for melatonin API in the health and wellness industry. Besides this, melatonin's recognized efficacy in managing jet lag has increased frequent travelers' usage, further driving market growth.

Which Factors Present Challenges to the Expansion of the Melatonin API Market?

“Limited Clinical Evidence, Perception and Misinformation, and Competition from Alternatives to Slow Down Market Growth”

The market for melatonin API is experiencing a setback due to limited clinical evidence on its long-term efficacy and safety. This has kept a substantial amount of people away from the market. Public perception also plays a crucial role in hindering the expansion of the melatonin API market. There are still a lot of misconceptions in the general population regarding the safety and effectiveness of melatonin API.

Apart from this, the market for melatonin API faces rigorous competition from other alternatives, such as prescription and over-the-counter sleep aids, herbal remedies, and pharmaceutical options. This diverts the consumer base as these alternatives are considered to be more effective and affordable than melatonin API. All these factors have collectively slowed down the market growth for melatonin API in the past few years.

Country-wise Insights

The North American melatonin API market is poised for exceptional growth, projecting a healthy CAGR of 17.80% through 2034. The surge is primarily attributed to increasing demand for melatonin API in key countries, notably the United States and Mexico. In 2024, the United States dominates the melatonin API industry with an estimated 91.90% market share.

Meanwhile, the East Asian melatonin API market is anticipated to exhibit substantial progress, aiming for a 19.50% CAGR in 2024. In this region, China emerges as the key player in the industry, commanding a significant share of 63.10% in 2024.

Why is the United States Leading the Melatonin API Market in North America?

“High Incidence of Sleep Disorders, Cultural Embrace of Supplements, and Consumer Spending Power in the Country to Augment Growth”

The North American market stood at US$ 1,039 million in 2024, acquiring a revenue share of 43.80%, and is further projected to expand at a CAGR of 17.80% through 2034. The United States melatonin API industry is estimated to be worth US$ 955 million in 2024. The demand for melatonin API in the United States is likely to rise at a CAGR of 17.80% through 2034.

According to a health report, about 50 to 70 million Americans have sleep disorders, and 1 in 3 adults (about 84 million people) do not regularly get the recommended amount of uninterrupted sleep they need to protect their health. This has resulted in a surge in sleep-inducing supplements, like melatonin API, in the United States.

This surge in demand is also due to the widespread acceptance of dietary supplements, including melatonin, for overall well-being. Apart from this, the relatively higher disposable income in the United States allows consumers to invest in health and wellness products, which has driven the market growth for melatonin API.

Why is China Commanding the East Asian Melatonin API Market?

“Production Capabilities, Government Support, and Industry Expertise to Help Market Expansion”

The China melatonin API industry is estimated to be worth US$ 270 million in 2024, garnering a share of 63.1% in the East Asian region. The sales of melatonin API are likely to record a CAGR of 20.80% through 2034.

China is leading in the pharmaceutical manufacturing sector, including the production of melatonin API. The country's robust manufacturing infrastructure and capabilities contribute to its leadership in supplying melatonin. The country has also developed significant expertise in the production of high-quality melatonin API. Besides this, China's large population and the growing awareness of melatonin's benefits further drive demand.

Category-wise Insights

Based on the grade, the GMP segment is estimated to hold a 92.50% market share in 2024. Simultaneously, the non-GMP segment is anticipated to secure a 7.50% share, contributing significantly to the market's resource diversity and stability. Based on applications, the clinical use segment marks its dominance in the melatonin API industry, with a share of 83.4% in 2024.

Why is Synthetic Melatonin API Gaining Popularity in the International Marketplace?

“Consistent Quality, Cost-Effectiveness, and Sustainable Production”

Despite the global push toward natural and organic supplements, synthetic melatonin API is gaining a lot of popularity in the international marketplace. This rising traction is attributed to its consistent quality, which allows for precise control over the manufacturing process in each batch. These sourcing methods are also cost-effective, making the final price of the products appealing to a wider consumer base.

Manufacturers in this industry are also preferring synthetically sourced melatonin API as they are more environmentally sustainable than natural ones. This attracts a substantial amount of eco-conscious consumers to the market. Besides this, Synthetic melatonin API often exhibits better stability and a longer shelf life compared to natural sources. This makes the storage and transportation of melatonin API more convenient.

Competitive Landscape

Key players in the melatonin API market include Merck KGaA, Caesar & Loretz GmbH, EVONIK, Bio-Techne Corp., Cayman Chemical Company (Matreya), Spectrum Chemical, Caesar & Loretz GmbH, LGM Pharma, Flavine Europe GmbH, Ralington Pharma LLP, Simson Pharma Limited, Santa Cruz Biotechnology, Inc., Biosynth, Otto Chemie Pvt. Ltd., Pharmaffiliates Analytics and Synthetics P. Ltd., and Clearsynth Labs.

The global market for melatonin API is fragmented, with several companies in the East Asian region. China is one of the leading countries in this market due to the presence of numerous melatonin API manufacturers. These companies often collaborate with fitness gurus, social media celebrities, and health and wellness companies to market their products effectively. This collaboration helps them reach a wider consumer base, thus strengthening their market presence and fostering global growth. These companies are also pushing toward natural and sustainable trends to cater to the demands of eco-conscious consumers and businesses.

Recent Development

• In August 2023, Celmatix Inc. and Aché Laboratórios collaborated to investigate a novel peripherally preferred melatonin receptor agonist for women's health, focusing on polycystic ovary syndrome (PCOS). The discovery by Aché addresses a critical gap in the market for first-line treatments for various women's health indications. The collaboration aimed to advance understanding and potential treatments for PCOS.
• In October 2023, Natural ingredients supplier Nutraland USA launched Somato, a whole-food-derived melatonin ingredient sourced exclusively from tomatoes. Offering a natural alternative to synthetic melatonin, Somato is made from whole, dried tomatoes and provides a sustainable and consumer-friendly option for functional foods and dietary supplements.
• In January 2023, P&G Health successfully launched Vicks ZzzQuil NATURA in India. The gummy, infused with natural chamomile and lavender, featured Melatonin for quick sleep induction and vitamin B6 to alleviate tiredness and fatigue, offering consumers a natural and effective solution for a restful night's sleep.

Melatonin API Market – Segmentation

• Source:

  • Natural
  • Synthetic
  • Bio-Synthetic

• Grade:

  • GMP
  • Non-GMP

• Application:

  • Clinical
  • Research

•  Region:

  • North America
  • Latin America
  • Europe
  • Asia Pacific
  • The Middle East & Africa (MEA)