Oligonucleotide Synthesis Market

Oligonucleotide Synthesis Market Study by Reagents & Consumables, Equipment, and Synthesized Oligonucleotides for Research, Therapeutics, and Diagnostics from 2024 to 2034

Analysis of Oligonucleotide Synthesis Market Covering 30+ Countries Including Analysis of US, Canada, UK, Germany, France, Nordics, GCC countries, Japan, Korea and many more

Oligonucleotide Synthesis Market Outlook (2024 to 2034)

The global oligonucleotide synthesis market size is approximated at US$ 6.76 billion in 2024 and is foreseen to expand at a CAGR of 10.9% to reach US$ 19.01 billion by the end of 2034.

Increasing FDA approvals for oligonucleotides as therapeutic agents, a robust R&D pipeline of pharmaceutical and biotechnology companies, and a rise in clinical trials for new diseases are some of the factors driving the oligonucleotide synthesis market growth. The lifestyle changes are contributing to increasing cases related to genetic disorders further driving demand for oligonucleotide synthesis.

Several leading companies are investing in R&D to develop novel oligonucleotides. Oligonucleotide is a combination of nucleotides, each containing a phosphate group, sugar molecule (ribose in RNA and deoxyribose in DNA), and any one nitrogenous (thymine (T) in DNA, cytosine (C), adenine (A), guanine (G), or uracil (U) in RNA). The growing popularity of molecular diagnostic is an emerging oligonucleotide synthesis market trend.

  • Making a step forward in the field of targeted RNA medicines, researchers from Novo Nordisk and Aarhus University in 2023 discovered a new method for synthesis of oligonucleotide conjugates.

The presence of robust healthcare facilities, rising prevalence of genetic disorders, and rising investments in R&D are fuelling the market growth in North America.

  • North America is expected to hold 34.4% of the oligonucleotide synthesis market share by 2034.
  • The East Asian oligonucleotide synthesis market size is evaluated at US$ 1.17 billion in 2024.

Expanding healthcare sector, rising awareness of genetic disorders, and key market players focus on building plants in the region due to supportive policies is expected to drive the growth of the oligonucleotide synthesis market in East Asia.

Report Attributes Details
Oligonucleotide Synthesis Market Size (2024E) US$ 6.76 Billion
Forecasted Market Value (2034F) US$ 19.01 Billion
Global Market Growth Rate (2024 to 2034) 10.9% CAGR
South Korea Market Value (2034F) US$ 795.3 Million
Key Companies Profiled
  • Kaneka Eurogentec S.A.
  • TriLink Biotechnologies LLC
  • BioAutomation
  • Danaher Corporation
  • Dharmacon Inc.
  • Thermo Fisher Scientific Corporation
  • GE Healthcare
  • ATDBio Ltd.
  • Twist Bioscience
  • Merck KGaA
  • Integrated DNA Technologies Inc.
  • Sigma-Aldrich Corporation
  • Agilent Technologies
  • LGC Biosearch Technologies

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Which Dynamics are Driving Demand for Oligonucleotide Synthesis Solutions?

“Path-breaking Developments in Synthetic Chemistry Boosting Demand for Oligonucleotide Synthesis”

Oligonucleotides are primarily used in biological and forensic applications in research, disease diagnosis, and therapeutics. Natural oligonucleotides have been extensively used for the selection and determination of the DNA sequences such as hybridization probes or affinity purification, gene construction, and site-directed mutagenesis. In addition, they are used to inhibit gene expression in in-vitro studies for diagnostic purposes.

Rising usage of oligonucleotides is augmenting the need for technological developments in synthetic chemistry. Several biotechnology and pharmaceutical companies are thus engaged in the development of newer and advanced methods.

  • Integrated DNA Technologies recently developed oligonucleotides up to 200 base lengths which are used with mass spectrometry for manufacturing mini-genes.

Which Obstacles are Lowering Profits of Oligonucleotide Synthesis Companies?

“High Costs and Complexity of Oligonucleotide Synthesis”

Significance of synthetic oligonucleotides as therapeutic drugs for treating diseases has full-fledged significantly in the last decade. Though, there have been numerous instances in the past, wherein owing to high complications such as high cost & severe side effects, countless drugs have been inhibited or have been abortive in clinical trial phases. Such instances could become recurring and may restrict market growth to a certain extent. Furthermore complexity of oligonucleotide synthesis may also hamper the overall market growth.

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Is Oligonucleotide Synthesis a Profitable Market for New Companies?

“Focus on Research and Development Efforts to Develop Effective Oligonucleotide Synthesis Products”

Gene and cell therapies often struggle due to off-target effects. This may be due to engineered organisms interact unintended targets. Also, in the real world environment scalability of synthetic constructs is major concern. To address such concerns advanced gene editing tools such as (Clustered Regularly Interspaced Short Palindromic Repeats) CRISPR Systems are expected to be more effective.

New companies should invest in research and development activities to introduce advanced oligonucleotide synthesis technology. This move would aid them to cater to a wider consumer base and earn high profits.

  • Graphite Bio a United States based start-up has developed an UltraHDR platform based on CRISPR technology to utilize the full potential of gene editing for precise DNA repair.
  • Cardior a German start-up offers a non-coding RNA therapeutics for heart condition patients. The company is using an AAV (Adeno-associated Viruses) to deliver a synthetic ncRNA inhibitor to restore cardiac function and lower aberrant expression. The gene therapies that utilize oligonucleotides are expected to offer promising results in reversing such conditions.

Country-wise Analysis

According to Fact.MR, a market research and competitive intelligence provider, the United States is estimated to hold 87.5% of the North American market share in 2024. This can be driven by the presence of leading biotech companies in the country.

How is the United States Oligonucleotide Synthesis Market Evolving?

“Hefty Investments in R&D to Drive Demand for Advanced Oligonucleotide Synthesis”

Attribute United States
Market Value (2024E) US$ 2.16 Billion
Growth Rate (2024 to 2034) 12.7% CAGR
Projected Value (2034F) US$ 7.15 Billion

The United States hold a supreme position in the North American market. The fast-growing life science industry, greater focus on genetics and genomics in research and diagnostic applications, and increasing demand for high-quality oligonucleotides are attributed as key growth drivers.

Pharmaceutical companies concentrating on oligonucleotides as therapeutic agents such as antisense and RNAi therapeutics are increasing in the region. These companies are making hefty investments in molecular diagnostics and clinical applications for developing new drugs and vaccines for children and prevention of HIV/AIDS which requires extensive research, thereby fostering the demand for oligonucleotide synthesis.

Why are Oligonucleotide Synthesis Providers Venturing into South Korea?

“Upsurge in Life Science Research Projects to Boost Adoption of Oligonucleotide Synthesis”

Attribute South Korea
Market Value (2024E) US$ 269 Million
Growth Rate (2024 to 2034) 11.4% CAGR
Projected Value (2034F) US$ 795.3 Million

South Korea market is expected to expand at a high pace in East Asia during the forecast period, owing to its emergence as the most promising life science research hub. An increase in life science research & development and a rise in government initiatives, grants, funds, and dedicated research commercial zones are attracting domestic and foreign market players to invest in the South Korea market.

Oligonucleotides have enormous latent applications in curing an extensive array of medical conditions. They allow the expansion of therapeutics as the crashing genes to be targeted, manipulated, silenced, and/or modulated.

Will Demand for Oligonucleotide Synthesis Increase in Germany?

“Wider Earning Scope for Oligonucleotide Synthesis Producers”

German companies are focusing on the production of more efficient and greener oligonucleotide synthesis chemistry. Oligonucleotides are gaining traction in various applications such as research, therapeutics, drug discover, forensic, and agriculture. Oligonucleotides are also experiencing increasing use in forensic and biological applications as sequence-specific binding agents in Germany.

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Category-wise Analysis

Apart from research oligonucleotide synthesis are finding applications in therapeutics. The standing of synthetic oligos as therapeutic drugs for nursing diseases has grown remarkably in the last decade. A few of the crucial drivers for this growth are the classification of more targets following the recognition of the human genome, progressions in antisense oligos, and the expansion of double-stranded siRNA oligos.

Therapeutic oligos are also beneficial in treating diseases ranging from viral infections, respiratory diseases, cancer, and rare diseases such as Duchenne Muscular Dystrophy (DMD), cystic fibrosis, and thrombotic thrombocytopenic purpura. Therapeutic oligonucleotides such as antisense oligonucleotides and nucleic acid aptamers are the two major types of therapies available in the market.

What is a Key Application Area of Oligonucleotide Synthesis?

“Major Use of Oligonucleotide Synthesis in Research Activities”

Attribute Research
Segment Value (2024E) US$ 2.68 Billion
Growth Rate (2024 to 2034) 11.7% CAGR
Projected Value (2034F) US$ 8.09 Billion

Research is emerging as a key application area, attributing to the potential of using oligonucleotide synthesis in polymerase chain reactions (PCR) and next-generation sequencing. The rising demand for drug development and discovery is anticipated to provide impetus to market growth.

Furthermore, ongoing improvements such as the induction of high throughput synthesizers, better coupling reagents, enhanced polymer supports, novel sets of protecting groups for exocyclic amino groups of nucleic bases, and the introduction of universal polymer supports are completely transforming the whole field of nucleic acids chemistry. A huge number of oligos are generally used in several research technologies such as PCR, qPCR/RT qPCR, gene synthesis, sequencing, and SNP analysis.

Which are Prime Products of Oligonucleotide Synthesis?

“Reagents & Consumables Exhibiting Increasing Application in Oligosynthesis at Lab Scale or Production Levels”

Attribute Reagents & Consumables
Segment Value (2024E) US$ 3.43 Billion
Growth Rate (2024 to 2034) 11.1% CAGR
Projected Value (2034F) US$ 9.86 Billion

Reagents & consumables are set to hold major global market share by 2034. Solvents and reagents play important role in DNA and RNA synthesis. Effective reagents & consumables for oligonucleotide synthesis help to reduce particulate contamination. Thus, reagents & consumables are witnessing increasing demand in pharmacogenomics, therapeutics, diagnostics, and drug discovery applications.

Competitive Landscape

Key players in the oligonucleotide synthesis market are reliant on partnerships, collaborations, acquisitions, and new software launches to stay afloat. Constant innovations to ensure a seamless client-customer relationship are the main focus of prominent market players.

  • In January 2021, Thermo Fisher Scientific Inc. and Groupe Novasep SAS (Novasep) announced that Thermo Fisher completed the acquisition of Henogen S.A., Novasep’s viral vector manufacturing business for approximately 725 Million Euros in cash in Belgium.

Key Segments of Oligonucleotide Synthesis Market Research

  • By Product :

    • Reagents & Consumables
    • Equipment
    • Synthesized Oligonucleotides
      • DNA Oligonucleotides
      • RNA Oligonucleotides
  • By Application :

    • Research
      • Polymerase Chain Reaction (PCR)
      • Next-Generation Sequencing
      • Others
    • Therapeutics
      • Antisense Oligonucleotides
      • Nucleic Acid Aptamers
    • Diagnostics
  • By End User :

    • Biotechnology & Pharmaceutical Companies
    • Research Institutes
    • Diagnostic Laboratories
  • By Region :

    • North America
    • Latin America
    • Europe
    • East Asia
    • South Asia & Oceania
    • Middle East & Africa

- FAQs -

What is oligonucleotide synthesis market size in 2024?

The global oligonucleotide synthesis market is calculated at US$ 6.76 billion for 2024.

What are the projected sales for oligonucleotide synthesis by 2034?

The market for oligonucleotide synthesis is forecasted to reach US$ 19.01 billion by 2034.

How big is the CAGR of the oligonucleotide synthesis market?

The global market is set to register a CAGR of 10.9% through 2034.

What are the raw materials for oligonucleotide synthesis?

In the context of oligonucleotide synthesis, raw materials used are called ucleoside phosphoramidites.

Who are leading end users of oligonucleotide synthesis?

Biotechnology & pharmaceutical companies are forecasted to hold 50.3% of the global market share by 2034.

Who are the key oligonucleotide synthesis companies in the market?

Leading producers include Thermo Fisher Scientific Corporation, Integrated DNA Technologies Inc., Sigma-Aldrich Corporation, and GE Healthcare.

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Oligonucleotide Synthesis Market

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