Path-breaking Developments in Synthetic Chemistry to Bolster Growth of Global Oligonucleotide Synthesis Market
Oligonucleotides are primarily used in biological and forensic applications in research, disease diagnosis, and therapeutics. Natural oligonucleotides have been extensively used for selection and determination of the DNA sequences such as hybridization probes or affinity purification, gene construction and site-directed mutagenesis. In addition, they are used to inhibit gene expression in in-vitro studies for diagnostic purposes.
Increased usage of oligonucleotides has augmented the need for technological developments in synthetic chemistry. Several biotechnology and pharmaceutical companies are thus engaged in the development of newer and advanced methods.
For instance, Integrated DNA Technologies has developed oligonucleotides up to 200 base length which is used with mass spectrometry for manufacturing mini-genes. On the back of these trends, the global oligonucleotides synthesis market is anticipated to expand at a CAGR of 11.3% during the forecast period (2020-2025).
Therapeutics Application Mainstays for Oligonucleotide Synthesis, Research Segment to Catch-Up
Oligonucleotide synthesis is anticipated to find maximum application in therapeutics, as oligonucleotide therapeutics are hailed as the third major drug-development platform, next to small molecules and biologics.
Therapeutic oligonucleotides such as antisense oligonucleotides and nucleic acid aptamers are the two major types of therapies available in the market. These are suitable for treating muscle dystrophy, cancer and other neurological disorders. Usage of oligonucleotide synthesis in therapeutics is expected to grow at a stellar CAGR of 18.4% during the forecast period.
Following therapeutics, research emerges as a key application area, attributing to the potential of using oligonucleotide synthesis in polymerase chain reactions (PCR) and next generation sequencing. Moreover, rising demand for drug development and discovery is anticipated to provide impetus to the market growth. Application of oligonucleotide synthesis in research is anticipated to register a CAGR of 10.0% through 2025.
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North America Leads the First Wave of Growth, Asia Pacific Promises New Opportunities
Asia Pacific is poised to expand most rapidly amongst all the regional markets during the forecast period, owing to its emergence as the world’s most promising life science research hub. Increase in life science research & development in developing economies and rise in government initiatives, grants, funds, and dedicated research commercial zones have attracted domestic and foreign market players to invest in the Asia Pacific’s market. The regional market is anticipated to expand at a staggering CAGR of 12.5% during the forecast period.
North America continues to reign supreme in the oligonucleotide synthesis market and is expected to expand at a CAGR of 10.0% through 2025. A fast growing life science industry, greater focus on genetics and genomics in research and diagnostic applications, and increased demand for high-quality oligonucleotides are attributed as key growth drivers.
Moreover, pharmaceutical companies concentrating on oligonucleotides as therapeutic agents such as antisense and RNAi therapeutics are increasing in the region.
Key Players Prioritize New Product Development for Competitive Edge
The global oligonucleotide market is fragmented, with the top three players accounting for less than two-fifths share of the market. Some important players are: Thermo Fisher Scientific Corporation, Integrated DNA Technologies, Inc., Sigma-Aldrich Corporation (a part of Merck KGaA), GE Healthcare, Kaneka Eurogentec S.A., TriLink Biotechnologies, LLC (Maravai Life Sciences), BioAutomation and ATDBio Ltd., to name a few.
Integrated DNA Technologies is one of the leading players in the global oligonucleotide synthesis market, which supplies custom oligonucleotides for academic and pharmaceutical research as well as pharmaceutical drug development. It has a strong focus on delivering excellent customer service. Its products include the Ultramer DNA Oligos and Primer Mix DNA Plate Oligos.
BioAutomation, another player, provides automation solutions to research institutes to enable them to conduct research and development studies in the biotechnology industry. Its products include the MerMade 48X oligonucleotide synthesizer, the MerMade 96E oligonucleotide synthesizer and the MerMade 192E/R/X oligonucleotide synthesizers.
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COVID-19 Impact Analysis
As the coronavirus pandemic tightens its iron-grip across the world, demand for effective diagnosis and treatment has also risen in the past 3-4 months. Presently, the most prevalent method of diagnosis of COVID-19 is through the real time polymerase chain reaction (RT-PCR) testing. However, pharmaceutical companies and healthcare providers are in the process of discovering more efficient ways of detecting the SARS-CoV-2 and preventing its spread among the patients.
In this respect, oligonucleotide cocktails are proving extremely useful. Vendors such as bioSynthesis are developing oligonucleotide-based testing kits since the onset of the COVID-19. Some of its ready-to-use cocktail mixes include the SARS-CoV-2 N1 Oligo Mix, the SARS-CoV-2 N2 Oligo Mix and the Human RNase P (RP) Oligo Mix respectively.
Such breakthroughs are generating a level of optimism amongst healthcare providers and stimulating them to keep the anti-coronavirus battle raging. The result is further expected to lead to positive growth of the oligonucleotide synthesis market.
The Analyst’s Viewpoint
“Simplistic methods of oligonucleotide synthesis have paved the way for novel technologies, thereby generating lucrative research and development opportunities for important manufacturers and stakeholders. Rapid synthesis and distribution of oligonucleotides has become paramount in assuring successful drug discovery enterprises.”
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Global Oligonucleotide Synthesis Market: Report Scope
The recent study on global oligonucleotide synthesis market by Fact.MR provides a detailed analysis for the forecast period 2020-2025. The report sheds light on the key growth dynamics responsible for shaping the future outlook. The report maps potential drivers, restraints and opportunities associated with the market’s proliferation. A detailed segmental analysis, based on product, application and end user, has been included in the report.
The abovementioned segments are further profiled across the North American, European, Asia-Pacific, Latin American and Middle East & African landscapes. Towards the end of the study, a detailed competitive landscape has been detailed.
In this section, information concerning the key market players, their revenue and market shares, product portfolios and key agreements has been provided. Lastly, a SWOT analysis of individual market players has been included to provide a realistic growth projection for the aforementioned forecast period.
Global Oligonucleotide Synthesis Market: Segmentation
Fact.MR has studied the global oligonucleotide synthesis market with detailed segmentation on the basis of product, application, end-user and region.
- Reagents & Consumables
- Synthesized Oligonucleotides:
- DNA Oligonucleotides
- RNA Oligonucleotides
- Polymerase Chain Reaction (PCR)
- Next-Generation Sequencing
- Antisense Oligonucleotides
- Nucleic Acid Aptamers
- Biotechnology & Pharmaceutical Companies
- Research Institutes
- Diagnostic Laboratories
- North America
- Asia Pacific
- Latin America
- Middle East & Africa (MEA)
“This taxonomy prepared is confidential and intended exclusively for the individual or entity with whom it is being shared. Reading, disseminating, distributing, or copying this to any party other than the addressee(s) is unauthorized and prohibited.”
Global Oligonucleotide Synthesis Market - Scope of the Report
The recent study by Fact.MR on global oligonucleotide synthesis market offers a 5-year forecast for the period of 2020-2025. The study analyzes crucial trends that are currently determining the growth of the global oligonucleotide synthesis market.
The study report explicates on vital dynamics such as the drivers, restraints and opportunities for key market players along with key stakeholders as well as emerging players associated with the production of oligonucleotides. The study also provides dynamics that are responsible for influencing the future status of the global oligonucleotide synthesis market over the forecast period.
A detailed assessment of the global oligonucleotide synthesis market value chain, business execution, and supply chain across the regional markets has been covered in the report. A list of prominent companies operating in the global oligonucleotide synthesismarket along with their product portfolio enhances the reliability of this comprehensive research study.
Global Oligonucleotide Synthesis Market: Report Summary
The study offers a comprehensive analysis on diverse features including production capacities, demand, product developments, revenue generation, and sales in the global oligonucleotide synthesis market.
A comprehensive estimate of the global oligonucleotide synthesis market has been provided through an optimistic as well as a conservative scenario, taking into account the adoption of oligonucleotide synthesis during the forecast period. Price point comparison by region with global average price is also considered in the study.
Global Oligonucleotide Synthesis Market: Size Evaluation
The global oligonucleotide synthesis market has been analyzed for each market segment, in terms of value (US$ Mn).
Market estimates at global and regional levels for oligonucleotide synthesisis are available in terms of ‘US$ Mn’ for value. A Y-o-Y growth contrast on prominent oligonucleotide synthesis market segments along with market attractiveness evaluation has been incorporated in the report.
Global Oligonucleotide Synthesis Market: Regional Market Assessment
Key sections have been elaborated in the global oligonucleotide synthesis market report, which have helped deliver projection on the regional markets. These chapters include the regional macros (political, economic, and business environment outlook) which are expected to have a momentous influence on the global oligonucleotide synthesis market growth during the forecast period.
Country-specific valuation on demand for oligonucleotide synthesis has been offered for each regional market, along with the market scope, estimate and forecast, price index, and impact analysis of dynamics of prominence in regions and countries. For all regional markets, Y-o-Y growth estimates have also been incorporated in the report.
Detailed breakup in terms of value for emerging countries has also been included in the report.
Global Oligonucleotide Synthesis Market: In-Depth Analysis on Competitive Landscape
The report sheds light on the leading companies operating in the global oligonucleotide synthesis market along with their detailed profiles. Essential and up-to-date data and information related to the market performers, who are principally engaged in the production of oligonucleotides, has been brought with the help of a detailed dashboard view. Market share analysis and comparison of prominent players provided in the report permit the report readers to take preemptive steps in advancing their businesses.
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