Bone Grafts and Substitutes Market

Bone Grafts and Substitutes Market Analysis By Product (Allografts, Synthetic Bone Grafts), By Material (Ceramic-based, Polymer-based, Growth Factor-based, Cell-based), By End User, By Region - Global Market Insights 2021-2028

Analysis of Bone Grafts and Substitutes market covering 30 + countries including analysis of US, Canada, UK, Germany, France, Nordics, GCC countries, Japan, Korea and many more

Bone Grafts and Substitutes Market Outlook (2021-2028)

The global bone grafts and substitutes market reached a valuation of US$ 3.06 Billion in 2020. Sales of bone grafts and substitutes are slated to rise at a CAGR of 4.9% to reach US$ 4.44 Billion by the end of 2028.

Report Attributes


Bone Grafts and Substitutes Market Size (2020)

US$ 3.06 Billion

Projected Year Value (2028)

US$ 4.44 Billion

Global Market Growth Rate (2021-2028)

4.9% CAGR

North America Market Share (2021-2028)


Key Companies Profiled

  • AlloSource
  • Integra LifeSciences
  • NuVasive, Inc.
  • Stryker
  • Wright Medical Group N.V.
  • Xtant Medical
  • Zimmer Biomet
  • Baxter Healthcare Corporation
  • Medtronic plc

Demand Analysis of Bone Grafts and Substitutes from 2017-2020 Vs Market Outlook for 2021-2028

“Growing Usage of Bone Grafts and Substitutes for Healing of Bone Injuries”

As per Fact.MR - a market research and competitive intelligence provider, the global market for bone grafts and substitutes was valued at US$ 3.06 Billion in 2020.

Bone grafts and substitutes (BGS) are materials that are used to replace missing bones or mend fractures in the bones. In the hip, foot, and ankle surgeries, as well as fractures and musculoskeletal injuries, BGS is commonly used. The primary goal of using bone grafts and substitutes is to aid in the healing of fractures and bone injuries, as well as to replace natural bone.

Bone Grafts and Substitutes Market forecast analysis by Fact.MR

Components of bone grafts and substitutes often comprise an osteoconductive matrix, which acts as a scaffold for the formation of new bone, osteoinductive proteins that promote the mitogenesis of similar bone cells, and osteogenic cells, which can create bone in the right environment. Bone morphogenetic proteins (BMPs) are important in the development of bone and cartilage.

Rising demand for synthetics and xenografts, growing usage of bone graft substitutes in regenerative medicines, and the increase in the number of illnesses that necessitate their usage would propel the market for bone grafts and substitutes forward. Furthermore, several prominent competitors offer a diverse range of bone graft products, which attracts a larger number of clients and promotes market expansion.

Demand for bone grafts and substitutes is predicted to increase at a CAGR of 4.9% from 2021 to 2028.

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Which Growth Factors are Driving Demand for Bone Grafts and Substitutes?

“Rise in Orthopedic Surgeries & R&D Initiatives to Boost Industry Expansion”

Growing usage of bone grafts and substitutes for musculoskeletal injuries and orthopedic procedures are driving the market growth. Bone grafts and substitutes are an excellent therapy option and are sometimes seen as vital, resulting in increased demand for these products. The rising frequency of bone cancer is likely to drive demand for bone grafts and substitutes.

Continuous R&D initiatives to generate unique product offerings is one of the most common trends in the worldwide industry. This rise in continuing R&D is encouraged by the rising need for effective bone graft substitutes for bone-related occurrences such as simple and severe fractures and trauma. Researchers from all over the world are working hard to find new ways to use bone grafts in regenerative medicines.

Furthermore, the ongoing efforts of several key companies in the market to produce biodegradable bone graft substitutes and polymeric materials will encourage customers to adopt bone grafts and alternative products, resulting in market growth.

Which Key Challenges are Faced by Bone Graft and Substitute Providers?

“High Cost of Surgery & Adverse Reactions of Products Restraining Market Growth”

Bone grafting surgeries have provided life-saving choices to a significant number of patients suffering from a variety of bone problems; nevertheless, risks associated with surgery failure and graft failure are projected to stifle market growth over the projection period.

Bone grafts and substitutes are a long-term solution for treating bone degeneration, but they are costly. The possibility of infections associated with allografts and synthetic bone grafts' low osteoinductive and osteoconductive potential is projected to restrain market expansion throughout the projection period.

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Which Region is Expected to Lead the Global Bone Grafts and Substitutes Market?

“Rising Number of Spine-related Disorders Driving Market Growth in North America”

North America is projected to account for 53.1% share of the bone grafts and substitutes market over the forecast period attributed to the rising prevalence of spine-related diseases, as well as the growing senior population.

Increased orthopedic surgical operations, a transition from non-biodegradable bone graft substitutes to biodegradable bone graft substitutes, and new product releases are expected to be the primary influencing factors in driving the bone grafts and substitutes market growth.

Country-wise Insights

What is Driving Growth of the U.S. Bone Grafts and Substitutes Market?

“Prominent Presence of Bone Graft and Substitute Suppliers Boosting Market Revenue”

The United States holds a significant portion of the market with the rising prevalence of sports injuries and joint problems, quick adoption of new technology, and an upgraded healthcare system, as well as the reimbursement scenario.

Arthritis is the biggest cause of disability among adults in the United States, according to the U.S. Arthritis Foundation. Around 54 million adults have been diagnosed with arthritis, and nearly 300,000 children have arthritis or a rheumatic illness, according to conservative estimates.

Growing public knowledge of commercially available new products, a strong presence of bone graft and substitute producers, and increased healthcare expenditure are all factors contributing to market expansion.

How is China Contributing to the Sales of Bone Grafts and Substitutes?

“Rising Medical Tourism to Propel Sales of Bone Grafts and Substitutes”

The bone grafts and substitutes market in China is growing due to an increase in the usage of allografts and other alternative products, a steady supply of orthopedic equipment, and a growing acceptance of autograft bone.

Increased medical tourism and favourable government initiatives will accelerate the market expansion in China. Market expansion is projected to be supported by increased public awareness and demand for regenerative therapies to improve treatment outcomes.

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Category-wise Insights

Why are Allografts Gaining Rapid Traction?

“Allografts Gaining Traction Attributed to Their Unique Properties”

Demand for allografts is set to increase at a significant rate owing to properties such as quick structural support and osteoconductivity. Allografts serve as a substitute for autografts and are divided into the demineralized bone matrix (DBM) and others.

Demineralized bone matrices, such as chips, pellets, and granules, are readily available in a variety of sizes and shapes. Allografts do not require numerous procedures to harvest bone, resulting in shorter surgery times and faster wound healing. As a result, allografts are commonly used in the spine, hip, and knee.

Which End User Holds a Dominant Stance in the Bone Grafts and Substitutes Market?

Hospitals Remain Dominant Owing to Availability of Advanced Therapies”

Hospitals are expected to dominate the global market during the forecast period because of the rising prevalence of various chronic bone disorders.

Rapid deployment of novel treatments and products such as bioresorbable scaffolds, orthopedic biomaterials, calcium phosphate synthetics, and calcium sulfate synthetics and rising orthobiologics sales in hospitals are driving the market growth.

Owing to the increasing number of patients who rely on medical settings for crucial orthopedic treatments such as spinal fusion, regenerative therapies, and joint reconstruction surgeries, hospitals are expected to be the most dominating section of the global market during the projection period.

COVID-19 Impact on Sales of Bone Grafts and Substitutes

The COVID-19 pandemic harmed the global market for bone grafts and substitutes. During the pandemic, most elective procedures were postponed or cancelled. As a result, the need for orthopedic surgery equipment, such as bone transplants and substitutes, decreased. Manufacturing activities were halted around the world, resulting in a drop in device production and orthobiologics sales.

New product launches, rising investments in the development of new bone graft substitutes, and efforts by important market players to strengthen distribution channels are projected to create lucrative prospects in the global bone grafts and substitutes market over the coming years.

Competitive Landscape

Manufacturers of bone grafts and substitutes are constantly investing in the development of new products with improved bioactivity, biocompatibility, and mechanical qualities. Companies have a varied product portfolio that is technologically advanced, as well as a larger global presence. Key players are constantly launching innovative products in various orthopedic application areas.

For instance,

  • The chronOS Strip bone graft substitute is made by Synthes, Inc., a Johnson & Johnson company. The chronOS-tricalcium phosphate granules in this synthetic bone transplant can be perfused with the patient's bone marrow and blood.

Key Segments Covered in Bone Grafts and Substitutes Industry Research

  • By Product:

    • Allografts
      • Demineralized Bone Matrix (DBM)
      • Others
    • Synthetic Bone Grafts
    • Others
  • By Material:

    • Ceramic-based 
      • Calcium Phosphate
      • Calcium Sulfate
      • Others
    • Polymer-based
      • Polylactides
      • Polyglycolides
      • Polyurethanes
      • Others
    • Growth Factor-based 
    • Cell-based 
    • Others
  • By End User:

    • Hospitals
    • Orthopedic Clinics
    • Others
  • By Region:

    • North America
    • Europe 
    • Asia Pacific 
    • Latin America
    • Middle East & Africa 

- FAQs -

The global bone grafts and substitutes market is estimated to exhibit a CAGR of 4.9% during the forecast period (2021-2028).

The bone grafts and substitutes market is expected to be valued at US$ 4.44 Billion by 2028.

North America, with 53.1% of the global market share, will largely contribute to the growth of bone grafts and substitutes revenue.

Increase in the geriatric population and rise in the prevalence of joint disorders drive market growth.

The global bone grafts and substitutes market was valued at US$ 3.06 Billion in 2020.

AlloSource, Integra LifeSciences, NuVasive, Inc., Stryker, and Wright Medical Group N.V. are key manufacturers of bone grafts and substitutes.

Bone Grafts and Substitutes Market

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