Progressive Multifocal Leukoencephalopathy Treatment Market
Progressive Multifocal Leukoencephalopathy Treatment Market Study by Anti-retroviral Therapies and Antiviral/Anti JCV, and Other Symptomatic from 2024 to 2034
Analysis of Progressive Multifocal Leukoencephalopathy Treatment Market Covering 30+ Countries Including Analysis of US, Canada, UK, Germany, France, Nordics, GCC countries, Japan, Korea and many more
Progressive Multifocal Leukoencephalopathy Treatment Market Outlook (2024 to 2034)
The global progressive multifocal leukoencephalopathy treatment market size is calculated to reach a valuation of US$ 143.3 million in 2024 and thereafter expand at a CAGR of 2.7% to end up at US$ 187.3 million by 2034.
Progressive multifocal leukoencephalopathy (PML) is a rare viral illness that causes progressive destruction of the brain's white matter in several sites. Progressive multifocal leukoencephalopathy kills the brain cells responsible for the CNS's protective layer (myelin). PML is active in around 2% to 6% of AIDS patients, most of whom have a CD4 level of less than 100.
The number of individuals identified in the context of immunosuppressive therapy for autoimmune illnesses is growing. Furthermore, persistent JCV infection with no symptoms is common in the general population. PML also occurs in people with hematological malignancies, multiple sclerosis, and organ transplants.
There is no known cure for this condition; however, medication can help alleviate symptoms. PML is most commonly documented in cancer patients on long-term immunosuppressive medicines or those suffering from AIDS. Developing treatment alternatives such as antiretrovirals and antivirals is expected to open up significant prospects for numerous new competitors in the advanced multifocal leukoencephalopathy therapy market, leading to progressive multifocal leukoencephalopathy treatment market growth.
Key Market Growth Drivers
- The rising incidence of hematological malignancies and the diagnosis of progressive multifocal leukoencephalopathy, along with the increasing rates of HIV infection in middle- and low-income countries, is driving market growth.
- Enhanced HIV testing and treatment, along with better detection and management of progressive multifocal leukoencephalopathy, coupled with advancements in healthcare facilities and government initiatives are benefitting treatment providers.
- The adoption of antiviral medications, immune response modulators, and vaccination therapy for potential progressive multifocal leukoencephalopathy patients is encouraging more widespread use of these technologies.
- Companies are focusing on developing novel treatments aimed at controlling the JC virus infection rather than merely enhancing immunity. Major players in the market are prioritizing improvements to existing treatments.
The medical community places a high focus on the discovery of innovative PML therapies due to the disease's catastrophic impact and the scarcity of accessible treatment choices. As more effective medications become available, the market for PML therapy is projected to expand. In recent years, there have been sincere efforts by government organizations and agencies such as WHO and pharmaceutical firms to promote awareness of progressive multifocal leukoencephalopathy treatments.
Report Attribute | Detail |
---|---|
PML Treatment Market Size (2024E) | US$ 143.3 Million |
Forecasted Market Value (2034F) | US$ 187.3 Million |
Global Market Growth Rate (2024 to 2034) | 2.7% CAGR |
Canada Market Growth Rate (2024 to 2034) | 2.9% CAGR |
Brazil Market Value (2034F) | US$ 7 Million |
North America Market Share (2024E) | 45.6% |
Latin America Market Share (2034F) | 7.8% |
Key Companies Profiled | Amgen Inc.; Boehringer Ingelheim International GmbH; Ipsen Pharma; Spectrum Pharmaceuticals Inc.; Takeda Pharmaceutical Company Limited; Dr Reddy Laboratories Ltd.; Apotex Inc.; F. Hoffman-La Roche Ltd.; Lilly; Merck & Co. Inc.; Mylan N.V; AbbVie Inc; Bristol-Myers Squibb Company; NeolmmuneTech; Inhibikase Therapeutics; Neurimmune; Gilead Sciences Inc.; Allergan Plc; Novartis AG. |
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Which Opportunities Await PML Treatment Providers?
“Increased Use of Immunosuppressive Medications and Advancements in Treatment Methodologies”
The global market for progressive multifocal leukoencephalopathy treatment is primarily driven by the rising prevalence of blood cancers, including multiple myeloma, the development of new and effective treatment options, advancements in treatment technologies, the development of new diagnostic technologies, and availability of better treatments.
The increasing frequency of cancers and the increased usage of immunosuppressive medications for autoimmune and other conditions are contributing to the expansion of the progressive multifocal leukoencephalopathy treatment market size. As a result, market participants are attempting to create new diagnostic tools and imaging methods that are expected to increase the accuracy of progressive multifocal leukoencephalopathy diagnosis.
- For example, in November 2021, Japan authorized Teserpaturev, the world's first oncolytic virus-based immunotherapy, providing new hope to people suffering from GBM, a malignant brain tumor. Teserpaturev is a genetically modified herpes simplex virus type 1 (HSV-1) that has the unusual capacity to destroy both the brain tumor cells it infects and those that have disseminated to other areas of the brain. This is accomplished by engaging the patient's immune system to combat the tumor.
“Convenience of Purchasing Drugs from Local Pharmacies Benefitting Patients”
Drug stores are the primary consumers of PML treatment medications. The majority of PML medicines sold in pharmacies are used by HIV patients who require lifelong medication. Drug shops provide convenience for the patients receiving this treatment, who may purchase medications from drug stores in their immediate vicinity.
Anti-JCV medicines are widely utilized to treat PML patients. They operate by reducing the viral load in the body, which may help alleviate symptoms. These medications are available in the form of orally ingestible tablets. Entecavir (Baraclude) and tenofovir (Viread) are two commonly used antiviral/anti-JCV medicines.
What is Restricting Access to Diagnostic and Therapeutic Options for PML?
“Expensive Hospitalization and Limited Healthcare Infrastructure in Developing Countries”
The market is expected to be greatly impacted by challenges such as the scarcity and high cost of advanced progressive multifocal leukoencephalopathy treatment alternatives. Expensive treatments and associated expenditures, including hospitalization, intensive care, and specialist diagnostic testing, are projected to impede market expansion. Furthermore, limited healthcare infrastructure, particularly in developing countries, might restrict access to progressive multifocal leukoencephalopathy treatment as well as diagnostic and therapeutic alternatives.
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Country-wise Evaluation
The market in Mexico is forecasted to expand at a CAGR of 2.9% from 2024 to 2034. The country is estimated to occupy a progressive multifocal leukoencephalopathy treatment market share of 5.5% in North America by the end of 2034.
What’s Driving Investments in Improving PML Treatment in the United States?
“Technological Capabilities of Pharmaceutical Firms Advancing Innovative Therapies”
Attribute | United States |
---|---|
Market Value (2024E) | US$ 57.1 Million |
Growth Rate (2024 to 2034) | 3.2% CAGR |
Projected Value (2034F) | US$ 78.1 Million |
The United States dominates the North American market. The presence of a large number of pharmaceutical companies investing heavily in the development of new, targeted treatments for the condition, high healthcare expenditures, and rising incidence of PML are key progressive multifocal leukoencephalopathy treatment market trends in the United States.
Why are Healthcare Providers Focusing on Brazil?
“Improved Access to Safe and Effective Therapy for Progressive Multifocal Leukoencephalopathy”
Attribute | Brazil |
---|---|
Market Value (2024E) | US$ 6 Million |
Growth Rate (2024 to 2034) | 1.8% CAGR |
Projected Value (2034F) | US$ 7 Million |
Rising treatment-seeking rates in Brazil, together with improved access to safe and effective therapy and accurate cancer diagnosis, are leading to an increase in progressive multifocal leukoencephalopathy diagnoses. The market in the country is influenced by rising HIV infection rates, improved HIV and cancer treatment rates, and rising awareness of the benefits of progressive multifocal leukoencephalopathy treatments.
Category-wise Insights
Based on drug type, anti-retroviral therapy is estimated to hold a market share of 13.1% in the year 2024.
Which Indication is PML Therapy Predominantly Used For?
“Widespread Adoption of Progressive Multifocal Leukoencephalopathy Therapy for HIV/AIDS”
Attribute | HIV/AIDS |
---|---|
Segment Value (2024E) | US$ 112.1 Million |
Growth Rate (2024 to 2034) | 2.6% CAGR |
Projected Value (2034F) | US$ 145.5 Million |
Rising prevalence of HIV infection in several middle- and low-income countries is projected to contribute to the growth of the market over the forecast period. Favorable reimbursement policies for HIV and cancer therapy are projected to fuel the uptake of progressive multifocal leukoencephalopathy treatment during the forecast period.
Which Distribution Channel Accounts for High Sales of PML Medications?
“Access to Specialized Medications and Continual Supply of Essential Drugs at Hospital Pharmacies”
Attribute | Hospital Pharmacies |
---|---|
Segment Value (2024E) | US$ 123.7 Million |
Growth Rate (2024 to 2034) | 2.6% CAGR |
Projected Value (2034F) | US$ 160.4 Million |
Hospital pharmacies are well-equipped to provide the specialized medications required for PML treatment. These pharmacies maintain a continual supply of high-cost, essential drugs that are often not available in retail pharmacies. This ensures that patients receive the exact medications they need without delays, which is crucial for managing PML effectively.
Know thy Competitors
Competitive landscape highlights only certain players
Complete list available upon request
Competition Realm
Key players in the progressive multifocal leukoencephalopathy treatment market are improving their business tactics to grab more market share compared to other competitors. At the same time, they are adapting themselves to the evolving market trends.
- Teserpaturev was granted conditional and temporary marketing permission in Japan in June 2021 for the treatment of malignant glioma, based on the findings of a Japanese phase 2 clinical study in GBM patients. The experiment found that 92% of patients who underwent Teserpaturev immunotherapy were still alive one year later, which is much higher than the normal 15% one-year survival rate in this group of patients undergoing traditional late-stage brain tumor therapies.
- Cellevolve Bio, Inc., a business focusing on developing and commercializing cell treatments, reported in October 2022 that its Investigational New Drug (IND) application for CE-VST01-JC has been approved by the US FDA. CE-VST01-JC is a JC Virus-Specific T Cell Therapy being researched for the treatment of progressive multifocal leukoencephalopathy (PML) and has been designated an orphan medication by the FDA.
Fact.MR provides detailed information about the price points of key progressive multifocal leukoencephalopathy treatment providers positioned across the world, sales growth, production capacity, and speculative technological expansion, in this new market report.
Key Segments of PML Treatment Market Research
-
By Drug Type :
- Anti-retroviral Therapies
- Antiviral/Anti-JCV
- Other Symptomatic Treatments
-
By Indication :
- HIV/AIDS
- Organ Transplantations
- Multiple Sclerosis
- Hematological Malignancies
-
By Distribution Channel :
- Hospital Pharmacies
- Drug Stores
- Retail Pharmacies
-
By Region :
- North America
- Latin America
- Eastern Europe
- Western Europe
- East Asia
- South Asia & Pacific
- Middle East & Africa
- FAQs -
What is the market size of progressive multifocal leukoencephalopathy treatment?
The global market for PML treatment is projected to reach US$ 143.3 million in 2024.
Who are the leading players in the progressive multifocal leukoencephalopathy treatment market?
Prominent market players are Amgen Inc, Boehringer Ingelheim International GmbH, and Ipsen Pharma.
How is the market for PML treatment expected to perform in Mexico?
The Mexico market is estimated to advance at a CAGR of 2.9% between 2024 and 2034.
What are the global PML market projections?
The PML market is projected to expand at a CAGR of 2.7% and reach US$ 187.3 million by the end of 2034.
How is the market for PML treatment faring in Chile?
The Chile market is forecasted to advance at a CAGR of 1.6% between 2024 and 2034.
Which indication accounts for higher revenue generation?
The organ transplantation segment is forecasted to reach a valuation of US$ 12.2 million in 2024.