Joint Replacement Market Analysis and Forecast by Fact.MR

  • The global market for joint replacement is estimated to be around US$ 23 billion in 2025 and has been forecast to expand at a CAGR of 5.4% to end up at US$ 41.02 billion by 2036.
  • Surgical volume expansion and Implant material innovation are shaping the demand landscape.
  • Growth is supported by structural shifts in healthcare / orthopedics procurement, regulatory requirements, and technology adoption across both developed and emerging markets.

Joint Replacement Market  Value Analysis

Summary of the Joint Replacement Market

  • Market Snapshot
    • In 2025, the global Joint Replacement Market was valued at approximately USD 23 billion.
    • The market is estimated to reach USD 24.24 billion in 2026 and is projected to attain USD 41.02 billion by 2036.
    • The joint replacement market is likely to expand at a CAGR of 5.4% during the forecast period.
    • The market is anticipated to create an absolute dollar opportunity of USD 16.78 billion between 2026 and 2036.
    • Knee Replacement Implants accounts for 48% of product share in 2026.
    • India (7.5%) and China (7.2%) are the key growth markets during the forecast period.
  • Demand and Growth Drivers
    • Rising prevalence of osteoarthritis in aging populations globally is increasing surgical volume for knee and hip replacement procedures.
    • Growing adoption of robotic-assisted surgery systems improving implant positioning accuracy and reducing post-surgical recovery time.
    • Expanding ambulatory surgical center capacity for joint replacement procedures is reducing surgical costs and improving patient throughput.
  • Product and Segment View
    • Knee Replacement Implants accounts for 48% of product share in 2026, emerging as the leading segment due to established market presence and strong buyer preference.
    • Osteoarthritis Treatment accounts for 55% share in 2026, making it the dominant use case driven by growing healthcare / orthopedics demand.
  • Key segmentation includes:
    • Product: Knee Replacement Implants, Hip Replacement Implants, Shoulder Replacement Implants, Elbow Replacement Implants, Revision Joint Systems
    • Application: Osteoarthritis Treatment, Rheumatoid Arthritis, Trauma and Fracture Repair, Congenital Joint Disorders
    • End Use: Hospitals, Ambulatory Surgical Centers, Specialty Orthopedic Clinics, Rehabilitation Centers
    • Technology: Robotic Assisted Surgery Systems, Minimally Invasive Surgery Systems, Custom Implant Technology, Advanced Bearing Surfaces
    • Formulation: Implantable Prosthetic Systems, Cementless Fixation Systems, Hybrid Fixation Systems, Revision Implant Systems
    • Distribution Channel: Direct Sales, Specialty Distributors, Government Procurement
  • Geography and Competitive Outlook
    • North America is a leading regional market supported by strong institutional demand, established procurement channels, and high adoption of advanced joint replacement technologies.
    • Europe is experiencing steady demand supported by regulatory frameworks, research infrastructure, and established healthcare systems.
    • Asia Pacific is becoming a growth area as value-based care models and expanding institutional capacity create new demand channels.
    • India (7.5%) and China (7.2%) are the key growth markets, while UK and Germany maintain steady growth.
    • Key companies in this market include Stryker Corporation, Zimmer Biomet Holdings Inc., Johnson & Johnson (DePuy Synthes Inc.), Smith & Nephew Plc., DJO Global Inc. (Enovis).
  • Analyst Opinion
    • Shambhu Nath Jha, Principal Consultant at Fact.MR, says 'The joint replacement market is shifting from a volume-driven surgical commodity toward a technology-differentiated ecosystem. Robotic-assisted systems are changing how surgeons plan and execute procedures, and hospitals that invest in these platforms are capturing more referrals. At the same time, the push toward outpatient arthroplasty is compressing cost structures and rewarding manufacturers that can offer value-engineered implant systems without compromising clinical outcomes. Companies that combine reliable implant performance with digital surgery platforms and post-operative monitoring are better positioned to retain hospital contracts.'

Key Growth Drivers, Constraints, and Opportunities

Joint Replacement Market Opportunity Matrix Growth Vs Value

Key Factors Driving Growth

  • Rising prevalence of osteoarthritis in aging populations globally is increasing surgical volume for knee and hip replacement procedures.
  • Growing adoption of robotic-assisted surgery systems improving implant positioning accuracy and reducing post-surgical recovery time.
  • Expanding ambulatory surgical center capacity for joint replacement procedures is reducing surgical costs and improving patient throughput.

Key Market Constraints

  • High cost of robotic surgery platforms and patient-specific implants limits adoption in price-sensitive healthcare settings.
  • Implant supply chain concentration in a few large manufacturers creates pricing rigidity and procurement challenges for smaller hospital systems.
  • Shortage of trained orthopedic surgeons in emerging markets restricts procedure volumes despite rising clinical demand.

Key Opportunity Areas

  • 3D-printed patient-specific implants are creating a premium product tier with improved anatomical fit and surgical outcomes.
  • Outpatient joint replacement protocols in ambulatory settings are lowering per-procedure costs and expanding the addressable patient population.
  • Growth of revision arthroplasty driven by aging implant populations creates a secondary demand cycle for complex reconstruction systems.

Segment-wise Analysis of the Joint Replacement Market

  • Knee Replacement Implants holds 48% of the product segment in 2026, supported by strong buyer preference and established market positioning.
  • Osteoarthritis Treatment represents 55% of the application segment in 2026, with surgical volume expansion acting as the primary demand channel.
  • Robotic Assisted Surgery Systems accounts for 44% of the technology segment in 2026, reflecting strong adoption across institutional and commercial applications.

The joint replacement market is segmented by product, application, end use, technology, formulation, distribution channel, and region. By product, the market covers Knee Replacement Implants, Hip Replacement Implants, Shoulder Replacement Implants, Elbow Replacement Implants, Revision Joint Systems.

Which Product Segment Dominates the Joint Replacement Market?

Joint Replacement Market Analysis By Product

Knee Replacement Implants is expected to be the dominant product segment in the Joint Replacement Market with 48% share in 2026. Demand is supported by established buyer preference, strong installed base, and growing adoption across both developed and emerging markets. The segment benefits from proven performance, competitive pricing, and integration with established healthcare / orthopedics workflows.

Other segments in this category include Hip Replacement Implants, Shoulder Replacement Implants, Elbow Replacement Implants, Revision Joint Systems, each serving specific buyer needs and use case requirements. Knee Replacement Implants is expected to maintain its position through 2036 as the primary demand channel continues to expand across key geographies.

Which Application Segment Dominates the Joint Replacement Market?

Joint Replacement Market Analysis By Application

Osteoarthritis Treatment is expected to be the dominant application segment in the Joint Replacement Market with 55% share in 2026. Demand is supported by established buyer preference, strong installed base, and growing adoption across both developed and emerging markets. The segment benefits from proven performance, competitive pricing, and integration with established healthcare / orthopedics workflows.

Other segments in this category include Rheumatoid Arthritis, Trauma and Fracture Repair, Congenital Joint Disorders, each serving specific buyer needs and use case requirements. Osteoarthritis Treatment is expected to maintain its position through 2036 as the primary demand channel continues to expand across key geographies.

Which Technology Segment Dominates the Joint Replacement Market?

Joint Replacement Market Analysis By Technology

Robotic Assisted Surgery Systems is expected to be the dominant technology segment in the Joint Replacement Market with 44% share in 2026. Demand is supported by established buyer preference, strong installed base, and growing adoption across both developed and emerging markets. The segment benefits from proven performance, competitive pricing, and integration with established healthcare / orthopedics workflows.

Other segments in this category include Minimally Invasive Surgery Systems, Custom Implant Technology, Advanced Bearing Surfaces, each serving specific buyer needs and use case requirements. Robotic Assisted Surgery Systems is expected to maintain its position through 2036 as the primary demand channel continues to expand across key geographies.

Which Product Trend is Shaping the Next Phase of Growth in the Joint Replacement Market?

Robotic-assisted surgery systems are not yet the largest technology segment, but they are emerging as the fastest-growing part of the joint replacement market. Their share is projected to rise as more hospitals invest in computer-navigated platforms that improve implant alignment, reduce revision rates, and support surgeon training standardization. This is especially relevant in markets where surgical precision and outcome documentation are tied to reimbursement and quality benchmarks.

The shift toward robotic platforms reflects a broader change in hospital purchasing priorities. Orthopedic departments increasingly want surgical planning tools that integrate pre-operative imaging with intra-operative guidance. As a result, robotic systems are moving from early-adopter academic centers into community hospital settings, particularly where competitive pressure and patient volume justify the capital investment.

Regional Outlook Across Key Markets

Top Country Growth Comparison Joint Replacement Market Cagr (2026 2036)

  • India leads growth at 7.5%, supported by expanding surgical access programs, growing medical tourism for orthopedic procedures, and rising middle-class demand for elective joint replacement.
  • China follows at 7.2%, with government healthcare reform, increasing orthopedic surgical capacity, and growing adoption of minimally invasive implant systems driving volume growth.
  • North America shows mature but steady growth, with the U.S. at 5.0% supported by high procedure volumes, strong robotic surgery adoption, and established implant reimbursement pathways.
  • Europe maintains consistent demand, with Germany at 4.8% and the UK at 4.9%, supported by national joint registries, clinical outcome tracking, and aging population demographics.

CAGR Table

Country CAGR (%)
India 7.5%
China 7.2%
Japan 5.3%
USA 5%
UK 4.9%

Source: Fact MR (FMR) analysis, based on proprietary forecasting model and primary research.

Joint Replacement Market Cagr Analysis By Country

Market Outlook for Joint Replacement in India

The India Joint Replacement market is projected to grow at a CAGR of 7.5% through 2036. Demand is supported by a large untreated osteoarthritis population, expanding surgical access through government health schemes, and growing medical tourism for orthopedic procedures.

  • Government schemes are expanding surgical access in public hospitals.
  • Medical tourism sustains premium implant demand.
  • Rising middle-class healthcare spending supports elective surgery growth.

China Joint Replacement Demand Trends

The China Joint Replacement market is projected to grow at a CAGR of 7.2% through 2036. Growth is supported by aging demographics, expanding orthopedic surgical capacity, and rising adoption of domestic and imported implant systems across tier-1 and tier-2 hospital networks.

  • Aging demographics create sustained surgical demand.
  • Hospital expansion is increasing orthopedic procedure capacity.
  • Domestic implant manufacturing is improving price accessibility.

Japan Joint Replacement Growth Assessment

Joint Replacement Market Japan Market Share Analysis By Product

The Japan Joint Replacement market is projected to grow at a CAGR of 5.3% through 2036. Demand is supported by one of the oldest populations globally, high healthcare quality standards, and strong adoption of robotic-assisted surgery platforms in major hospital systems.

  • Aging population sustains high arthroplasty demand.
  • Robotic surgery adoption improves surgical outcomes.
  • Quality-focused healthcare system supports premium implants.

Joint Replacement Market Outlook in the United States

Joint Replacement Market Country Value Analysis

The U.S. Joint Replacement market is projected to grow at a CAGR of 5% through 2036. Demand is supported by high annual procedure volumes, strong robotic surgery platform adoption, and established insurance reimbursement for knee and hip arthroplasty.

  • High procedure volumes support steady implant demand.
  • Robotic platforms are expanding across hospital networks.
  • Ambulatory surgical centers are increasing outpatient procedure share.

UK Joint Replacement Demand Analysis

The UK Joint Replacement market is projected to grow at a CAGR of 4.9% through 2036. Demand is supported by NHS joint replacement pathways, national joint registry data driving implant selection, and growing adoption of patient-specific surgical planning.

  • NHS pathways support structured procurement cycles.
  • Joint registry data drives evidence-based implant selection.
  • Patient-specific planning is improving surgical accuracy.

Competitive Benchmarking and Company Positioning

Joint Replacement Market Analysis By Company

Joint Replacement Market Analysis By Company

  • Stryker Corporation, Zimmer Biomet Holdings Inc., and Johnson & Johnson (DePuy Synthes) hold strong positions in the global joint replacement market through broad implant portfolios, strong surgical training programs, and growing capabilities in robotic-assisted surgery platforms.
  • Smith & Nephew, DJO Global (Enovis), and Arthrex compete meaningfully across specific implant categories, price tiers, and regional distribution channels, with competition shaped by clinical evidence, surgeon relationships, and hospital contract terms.
  • Technology integration creates an important barrier to differentiation, especially in robotic surgery where platform compatibility, surgical planning software, and post-operative monitoring ecosystems influence hospital stickiness.

The competitive landscape is moderately fragmented, with a mix of established market leaders, specialized providers, and value-oriented participants. Stryker Corporation, Zimmer Biomet Holdings Inc., Johnson & Johnson (DePuy Synthes Inc.) compete strongly through product breadth, technology capabilities, and growing visibility across key application segments and geographic markets.

Below these leaders, Smith & Nephew Plc., DJO Global Inc. (Enovis), Arthrex Inc. maintain relevance across specific customer groups and channel positions. These players compete through a mix of pricing, product performance, and regional market access rather than through fully integrated platform ecosystems.

Key Companies in the Joint Replacement Market

  • Stryker Corporation, Zimmer Biomet Holdings Inc., Johnson & Johnson (DePuy Synthes Inc.), Smith & Nephew Plc. are among the leading players in the joint replacement market globally, supported by strong brand visibility, broad product portfolios, and growing positions in their respective market segments.
  • DJO Global Inc. (Enovis), Arthrex Inc., Exactech Inc. hold established positions across specific segments and channels.
  • MicroPort Orthopedics Inc., Conformis Inc., Corin Group Ltd. compete through focused offerings and niche positioning.

Recent Industry Developments

  • Stryker Corporation , Robotic Platform Expansion / Mako System Enhancement (2025)
    • Stryker expanded its Mako robotic-assisted surgery platform with updated software for total knee and hip applications, improving pre-operative planning accuracy and intra-operative feedback for surgeons.
  • Zimmer Biomet , Product Launch / Personalized Implant Technology (2026)
    • Zimmer Biomet launched next-generation patient-specific knee implants using advanced 3D printing and CT-based surgical planning, targeting improved anatomical fit and reduced revision risk.
  • Smith & Nephew , Technology Partnership / Digital Surgery Integration (2025)
    • Smith & Nephew expanded its CORI surgical system portfolio through technology partnerships aimed at integrating real-time data analytics and sensor-based implant positioning into orthopedic workflows.
  • DePuy Synthes (J&J) , Market Expansion / Ambulatory Surgery Program (2026)
    • DePuy Synthes expanded its ambulatory joint replacement program across select U.S. and European markets, supporting the shift toward outpatient arthroplasty with value-engineered implant solutions.

Leading Companies Shaping the Joint Replacement Market

  • Stryker Corporation
  • Zimmer Biomet Holdings Inc.
  • Johnson & Johnson (DePuy Synthes Inc.)
  • Smith & Nephew Plc.
  • DJO Global Inc. (Enovis)
  • Arthrex Inc.
  • Exactech Inc.
  • MicroPort Orthopedics Inc.
  • Conformis Inc.
  • Corin Group Ltd.

Sources and Research References

  • Stryker Corporation. Mako robotic platform and joint replacement product updates.
  • Zimmer Biomet Holdings Inc. Personalized implant technology and surgical planning portfolio.
  • Smith & Nephew. CORI surgical system and digital orthopedic integration updates.
  • World Health Organization (WHO), national joint registries, and orthopedic association databases.
  • Primary interviews with orthopedic surgeons, hospital procurement teams, implant distributors, and surgical technology providers.

This bibliography is provided for reader reference and is not exhaustive. The full report contains the complete reference list and detailed citations.

Key Questions This Report Addresses

  • What is the current and future size of the Joint Replacement Market?
  • How fast is the Joint Replacement Market expected to grow between 2026 and 2036?
  • Which product type is likely to lead the market by 2026?
  • Which application segment is expected to account for the highest demand by 2026?
  • What factors are driving demand for joint replacement globally?
  • How is the shift toward robotic-assisted surgery influencing the market?
  • Why is India emerging as the fastest-growing market?
  • How are ambulatory surgical centers supporting procedure volume growth?
  • Which countries are projected to show the fastest growth through 2036?
  • What is driving market expansion in India, China, and Japan?

Joint Replacement Market Definition

The joint replacement market covers implantable prosthetic systems, surgical instruments, and associated technologies used for total and partial joint reconstruction in knee, hip, shoulder, elbow, and revision arthroplasty procedures. It includes cemented, cementless, and hybrid fixation systems used across osteoarthritis, rheumatoid arthritis, trauma repair, and congenital joint disorder applications.

Joint Replacement Market Inclusions

  • The scope covers global and regional market size and forecasts for 2026 to 2036 across product type, application, end use, technology, formulation, distribution channel, and region.
  • It includes regional demand analysis across major geographies, based on factors such as surgical volume, orthopedic infrastructure, reimbursement frameworks, and demographic aging patterns.
  • The report includes pricing and cost analysis across implant categories, robotic surgery platforms, and surgical instrument systems, including procurement, installation, and maintenance costs.
  • It covers technology trends, market drivers and constraints, and the competitive landscape, including product portfolios, clinical evidence, hospital contracts, and distribution strategies of leading players.

Joint Replacement Market Exclusions

  • The scope excludes non-implant orthopedic products such as braces, supports, external fixation devices, and rehabilitation equipment not directly tied to joint replacement procedures.
  • It excludes sports medicine arthroscopy products, spine implants, dental implants, and cardiovascular implants not classified under joint replacement categories.
  • The report excludes pharmaceutical pain management products, physical therapy services, and post-operative rehabilitation programs sold without implant hardware.
  • It also excludes veterinary orthopedic implants, experimental tissue-engineered cartilage products, and non-commercial research prototypes without regulatory clearance.

Joint Replacement Market Research Methodology

  • The methodology combines secondary research, primary interviews, and forecast modelling.
  • It draws on 120+ secondary sources and benchmarks 65+ company product portfolios.
  • Market sizing covers 30+ countries through a demand-side model, supported by top-down validation.
  • Key inputs include healthcare / orthopedics activity levels, regulatory frameworks, infrastructure development, procurement patterns, and technology adoption rates.
  • The model cross-checks demand with procurement data, pricing trends, channel mix, and product launches.
  • Primary validation includes 25+ interviews across manufacturers, distributors, institutional buyers, and end users.
  • Final estimates go through trade-flow checks, sales-pattern review, and sensitivity testing.

Scope of Analysis

Joint Replacement Market Breakdown By Product, Application, And Region

Parameter Details
Quantitative Units USD 24.24 billion to USD 41.02 billion, at a CAGR of 5.4%
Market Definition The joint replacement market covers implantable prosthetic systems, surgical instruments, and associated technologies used for total and partial joint reconstruction in knee, hip, shoulder, elbow, and revision arthroplasty procedures.
Regions Covered North America, Latin America, Europe, East Asia, South Asia and Pacific, Middle East and Africa
Countries Covered India, China, Japan, USA, UK, Germany, France, 30 plus countries
Key Companies Stryker Corporation, Zimmer Biomet Holdings Inc., Johnson & Johnson (DePuy Synthes Inc.), Smith & Nephew Plc., DJO Global Inc. (Enovis), Arthrex Inc., Exactech Inc., MicroPort Orthopedics Inc., Conformis Inc., Corin Group Ltd.
Forecast Period 2026 to 2036
Approach Hybrid demand-side and top-down methodology with country-level demand analysis, product benchmarking, pricing analysis, and primary interviews

Joint Replacement Market Segmentation

  • Joint Replacement MarketSegmented by Product:

    • Knee Replacement Implants
      • Total Knee Arthroplasty Systems
        • Cemented Knee Implants
        • Uncemented Knee Implants
    • Hip Replacement Implants
      • Total Hip Arthroplasty Systems
        • Metal on Polyethylene Systems
        • Ceramic Hip Implants
    • Shoulder Replacement Implants
      • Total Shoulder Arthroplasty
        • Reverse Shoulder Systems
        • Anatomic Shoulder Implants
    • Elbow Replacement Implants
      • Partial Joint Systems
        • Hinged Elbow Implants
        • Modular Elbow Systems
    • Revision Joint Systems
      • Revision Arthroplasty Devices
        • Complex Reconstruction Systems
        • Failed Implant Replacement Kits
  • Joint Replacement MarketSegmented by Application:

    • Osteoarthritis Treatment
      • Degenerative Joint Disease
        • Age Related Joint Degeneration
        • Cartilage Wear Disorders
    • Rheumatoid Arthritis
      • Inflammatory Joint Disease
        • Autoimmune Joint Damage
        • Chronic Synovitis Management
    • Trauma and Fracture Repair
      • Post Traumatic Reconstruction
        • Accident Related Joint Damage
        • Sports Injury Reconstruction
    • Congenital Joint Disorders
      • Developmental Joint Abnormalities
        • Pediatric Reconstruction Cases
        • Structural Deformities Repair
  • Joint Replacement MarketSegmented by End Use:

    • Hospitals
      • Orthopedic Surgery Departments
        • Joint Replacement Centers
        • Trauma Care Units
    • Ambulatory Surgical Centers
      • Day Care Orthopedic Procedures
        • Minimally Invasive Surgeries
        • Short Stay Arthroplasty Units
    • Specialty Orthopedic Clinics
      • Joint Care Centers
        • Sports Medicine Clinics
        • Rehabilitation Orthopedic Units
    • Rehabilitation Centers
      • Post Surgical Recovery Centers
        • Physiotherapy Facilities
        • Mobility Restoration Units
  • Joint Replacement MarketSegmented by Technology:

    • Robotic Assisted Surgery Systems
      • Computer Navigation Systems
        • 3D Surgical Planning Systems
        • Real Time Navigation Tools
    • Minimally Invasive Surgery Systems
      • Image Guided Surgery
        • Precision Bone Cutting Systems
        • Alignment Correction Tools
    • Custom Implant Technology
      • Patient Specific Implants
        • 3D Printed Implants
        • Anatomical Fit Systems
    • Advanced Bearing Surfaces
      • Ceramic and Polyethylene Systems
        • Low Wear Implant Surfaces
        • High Durability Coatings
  • Joint Replacement MarketSegmented by Formulation:

    • Implantable Prosthetic Systems
      • Cemented Fixation Systems
        • Bone Cement Based Implants
        • Antibiotic Loaded Cement Systems
    • Cementless Fixation Systems
      • Porous Coated Implants
        • Osseointegration Surface Systems
        • Press Fit Implant Systems
    • Hybrid Fixation Systems
      • Combination Fixation Techniques
        • Partial Cement Systems
        • Dual Fixation Systems
    • Revision Implant Systems
      • Complex Reconstruction Systems
        • Bone Graft Integrated Implants
        • Custom Revision Prosthetics
  • Joint Replacement MarketSegmented by Distribution Channel:

    • Direct Sales
      • Manufacturer to Hospitals
        • Orthopedic Hospital Contracts
        • Large Healthcare Networks
    • Specialty Distributors
      • Orthopedic Device Vendors
        • Regional Surgical Suppliers
        • Implant Distribution Networks
    • Government Procurement
      • Public Health Tenders
        • National Joint Replacement Programs
        • Insurance Reimbursement Systems
  • Joint Replacement Marketby Region:

    • North America
      • USA
      • Canada
      • Mexico
    • Latin America
      • Brazil
      • Chile
      • Rest of Latin America
    • Western Europe
      • Germany
      • UK
      • Italy
      • Spain
      • France
      • Nordic
      • BENELUX
      • Rest of Western Europe
    • Eastern Europe
      • Russia
      • Poland
      • Hungary
      • Balkan & Baltic
      • Rest of Eastern Europe
    • East Asia
      • China
      • Japan
      • South Korea
    • South Asia and Pacific
      • India
      • ASEAN
      • Australia & New Zealand
      • Rest of South Asia and Pacific
    • Middle East & Africa
      • Kingdom of Saudi Arabia
      • Other GCC Countries
      • Turkiye
      • South Africa
      • Other African Union
      • Rest of Middle East & Africa

- Frequently Asked Questions -

How big is the joint replacement market in 2025?

The global joint replacement market is estimated to be valued at USD 23 billion in 2025.

What will be the size of the joint replacement market in 2036?

The market size for the joint replacement market is projected to reach USD 41.02 billion by 2036.

How much will the joint replacement market grow between 2026 and 2036?

The joint replacement market is expected to grow at a 5.4% CAGR between 2026 and 2036.

What are the key product types in the joint replacement market?

The key product types in the joint replacement market are Knee Replacement Implants, Hip Replacement Implants, Shoulder Replacement Implants, Elbow Replacement Implants, Revision Joint Systems.

Which application segment will contribute significant share in the joint replacement market in 2026?

In terms of application, Osteoarthritis Treatment is expected to account for 55% share in the joint replacement market in 2026.

Which countries are the fastest growing markets?

India (7.5%) and China (7.2%) are among the fastest-growing markets in the joint replacement market.

Who are the key companies in the joint replacement market?

Key companies include Stryker Corporation, Zimmer Biomet Holdings Inc., Johnson & Johnson (DePuy Synthes Inc.), Smith & Nephew Plc., DJO Global Inc. (Enovis).