Local Anesthesia Drugs Market
Local Anesthesia Drugs Market Size and Share Forecast Outlook 2025 to 2035
Local anesthesia drugs market is projected to grow from USD 4.3 billion in 2025 to USD 10.5 billion by 2035, at a CAGR of 9.3%. Lidocaine will dominate with a 29.4% market share, while injectable will lead the application segment with a 59.8% share.
Local Anesthesia Drugs Market Forecast and Outlook 2025 to 2035
The global local anesthesia drugs market is projected to reach USD 10.5 billion by 2035, recording an absolute increase of USD 6.2 billion over the forecast period. The market is valued at USD 4.3 billion in 2025 and is set to rise at a CAGR of 9.3% during the assessment period.
The overall market size is expected to grow by approximately 2.4 times during the same period, supported by increasing surgical procedure volumes and dental intervention requirements worldwide, driving demand for safe and effective pain management solutions and increasing investments in advanced drug delivery systems and formulation innovations globally.
Quick Stats for Local Anesthesia Drugs Market
- Local Anesthesia Drugs Market Value (2025): USD 4.3 billion
- Local Anesthesia Drugs Market Forecast Value (2035): USD 10.5 billion
- Local Anesthesia Drugs Market Forecast CAGR: 9.3%
- Leading Drug Type in Local Anesthesia Drugs Market: Lidocaine (29.4%)
- Key Growth Regions in Local Anesthesia Drugs Market: North America, Asia Pacific, and Europe
- Top Players in Local Anesthesia Drugs Market: Johnson & Johnson Services, Inc., Pfizer Inc., AstraZeneca plc, Novartis AG, Teva Pharmaceutical Industries Ltd., GSK plc, Sanofi S.A., Merck & Co., Inc., Aspen Holdings, Viatris Inc.

The healthcare and surgical sectors face mounting pressure to maintain superior patient comfort standards while meeting evolving safety requirements for procedure-based anesthesia, with modern local anesthesia drug products providing documented efficacy and rapid onset characteristics compared to general anesthesia alternatives for minor surgical procedures.
Rising outpatient surgery volumes and expanding dental care infrastructure development across emerging economies create substantial opportunities for manufacturers and healthcare providers. However, concerns about systemic toxicity and allergic reactions may pose obstacles to certain formulation expansions.
The lidocaine segment dominates market activity, driven by the extensive clinical application base requiring versatile anesthetic solutions with proven safety profiles across dental procedures, minor surgeries, and dermatological interventions worldwide. Healthcare professionals increasingly recognize the practical benefits of lidocaine formulations, with typical product offerings providing effective nerve blockade and manageable duration at accessible price points through established pharmaceutical distribution networks.
The bupivacaine segment maintains substantial market presence, serving surgical applications requiring longer-duration anesthesia for orthopedic procedures, cesarean sections, and post-operative pain management. Injectable applications emerge as the critical administration category, reflecting clinical emphasis on precise nerve blockade and surgical site infiltration requirements for controlled anesthetic delivery.
Surface anesthetic formulations demonstrate robust positioning, supported by rising demand for minimally invasive procedures and topical pain management driving adoption of gel and spray-based products.
Regional dynamics show diverse market opportunities with North America maintaining strong market leadership through extensive surgical infrastructure and advanced pain management protocols, while Asia Pacific demonstrates rapid expansion driven by healthcare system modernization and surgical volume growth.
India leads country-level growth through expanding outpatient procedure adoption and increasing healthcare accessibility, followed by China with cosmetic surgery market expansion and dental care infrastructure development.
The competitive landscape features moderate concentration with Johnson & Johnson Services, Inc. holding significant market leadership position, while established players including Pfizer Inc., AstraZeneca plc, Novartis AG, and other major pharmaceutical companies compete through comprehensive product portfolios and advanced formulation capabilities across diverse clinical applications.
Local Anesthesia Drugs Market Year-over-Year Forecast 2025 to 2035
Between 2025 and 2029, the local anesthesia drugs market is projected to expand from USD 4.3 billion to USD 6.1 billion, resulting in a value increase of USD 1.8 billion, which represents 29.0% of the total forecast growth for the period. This phase of development will be shaped by rising demand for outpatient surgical procedures and dental interventions requiring safe anesthesia, product innovation in long-acting formulations with reduced systemic toxicity, as well as expanding integration with minimally invasive surgical techniques and ambulatory care settings. Companies are establishing competitive positions through investment in specialized pharmaceutical manufacturing, advanced drug delivery technologies, and strategic market expansion across surgical, dental, and dermatological applications.
From 2029 to 2035, the market is forecast to grow from USD 6.1 billion to USD 10.5 billion, adding another USD 4.4 billion, which constitutes 71.0% of the overall expansion. This period is expected to be characterized by the expansion of specialized drug applications, including liposomal formulations for extended pain control and combination products with vasoconstrictors tailored for specific surgical requirements, strategic collaborations between pharmaceutical companies and medical device manufacturers, and an enhanced focus on patient-controlled analgesia systems and targeted delivery mechanisms. The growing emphasis on enhanced recovery after surgery protocols in hospitals and rising patient preference for conscious sedation alternatives will drive demand for comprehensive local anesthesia drug solutions across diverse applications.
Local Anesthesia Drugs Market Key Takeaways
| Metric | Value |
|---|---|
| Market Value (2025) | USD 4.3 billion |
| Market Forecast Value (2035) | USD 10.5 billion |
| Forecast CAGR (2025-2035) | 9.3% |
Why is the Local Anesthesia Drugs Market Growing?
The local anesthesia drugs market grows by enabling surgeons and dental practitioners to maintain superior patient comfort standards while accessing effective pain management solutions without substantial systemic effects or recovery complexity.
Healthcare providers and surgical teams face mounting pressure to minimize patient discomfort and enable rapid procedure completion while managing diverse intervention requirements across surgical specialties and dental care settings, with modern local anesthesia drugs typically providing superior targeted pain control and faster patient recovery compared to general anesthesia alternatives for appropriate procedures, making pharmaceutical adoption essential for ambulatory care positioning.
The medical industry's need for safe and reversible nerve blockade with minimal cardiovascular effects creates demand for comprehensive local anesthetic solutions that can provide reliable surgical anesthesia, maintain hemodynamic stability, and ensure patient safety without compromising procedural efficiency or clinical outcomes.
Government initiatives promoting outpatient surgical care and healthcare cost containment drive adoption in ambulatory surgery centers, dental clinics, and dermatology practices, where drug safety has a direct impact on patient satisfaction and complication rates. The expanding cosmetic surgery sector has created sustained demand for safe local anesthetic products supporting elective procedures across all demographic segments.
Rising disposable incomes in emerging markets enable greater access to dental care and elective procedures requiring local anesthesia administration. However, regulatory restrictions on certain anesthetic agents and concerns about methemoglobinemia risk with specific formulations may limit utilization of certain local anesthesia drugs among pediatric populations and patients with contraindications.
Segmental Analysis
The market is segmented by drug type, application, and region. By drug type, the market is divided into lidocaine, bupivacaine, ropivacaine, chloroprocaine, prilocaine, benzocaine, and others.
Based on application, the market is categorized into injectable and surface anesthetic. Regionally, the market is divided into Asia Pacific, Europe, North America, Latin America, and mea.
By Drug Type, Which Segment Accounts for the Dominant Market Share?

The lidocaine segment represents the dominant force in the local anesthesia drugs market, capturing 29.4% of total market share in 2025. This established drug category encompasses solutions featuring proven safety profile and versatile application suitability, including rapid onset characteristics and intermediate duration properties that enable superior clinical flexibility across dental procedures, minor surgeries, and emergency interventions worldwide. The lidocaine segment's market leadership stems from its superior clinical advantages, with formulations capable of addressing diverse procedural requirements while maintaining excellent safety records and broad regulatory approval across all healthcare settings.
The bupivacaine segment maintains a substantial 21.8% market share, serving surgical applications requiring prolonged anesthesia for orthopedic procedures, obstetric interventions, and post-operative pain management requiring extended nerve blockade duration. These formulations offer long-acting anesthetic properties for complex surgical procedures and regional anesthesia techniques while providing sufficient efficacy to meet contemporary surgical demands. The bupivacaine segment demonstrates strong growth potential, driven by expanding orthopedic surgery volumes and increasing emphasis on post-operative pain control protocols.
Key clinical advantages driving the lidocaine segment include:
- Rapid onset of action enabling quick procedural initiation without extended patient waiting periods for anesthetic effect
- Established safety profile with extensive clinical experience supporting confident administration across diverse patient populations
- Versatile formulation options including plain solutions and epinephrine combinations enabling customized vasoconstriction for bleeding control
- Cost-effective pricing providing optimal value for high-volume dental and surgical applications across healthcare facilities
By Application, Which Segment Accounts for the Largest Market Share?

Injectable applications dominate the local anesthesia drugs landscape with approximately 59.8% market share in 2025, reflecting the critical role of infiltration and nerve block techniques in supporting precise surgical anesthesia and dental pain control across clinical practice worldwide. The injectable segment's market leadership is reinforced by procedural requirements for deep tissue anesthesia, controlled drug delivery, and targeted nerve blockade combined with superior efficacy in surgical field infiltration.
Surface anesthetic applications represent a significant category with 40.2% market share in 2025, demonstrating steady expansion through specialized requirements for topical mucous membrane anesthesia, dermatological procedures, and pre-injection site preparation requiring non-invasive pain management. This segment benefits from growing minimally invasive procedure adoption and patient preference for needle-free anesthetic administration where clinically appropriate.
Key market dynamics supporting application growth include:
- Surgical procedure expansion driven by outpatient surgery trends and minimally invasive techniques requiring reliable local anesthesia
- Dental care modernization requiring precise infiltration and block anesthesia for restorative and surgical dental procedures
- Integration of ultrasound-guided regional anesthesia techniques enabling accurate nerve localization and reduced anesthetic volumes
- Growing emphasis on topical formulations for pediatric applications and needle-phobic patients supporting surface anesthetic adoption
What are the Drivers, Restraints, and Key Trends of the Local Anesthesia Drugs Market?
The market is driven by three concrete demand factors tied to clinical outcomes. First, increasing outpatient surgical volumes and ambulatory care expansion create rising demand for safe and effective local anesthetic agents, with same-day surgery representing rapidly growing healthcare delivery model worldwide, requiring comprehensive drug availability.
Second, dental care accessibility improvements and preventive dentistry emphasis drive increased adoption of local anesthesia products, with many countries implementing public dental health programs and expanding dental insurance coverage by 2030. Third, technological advancements in liposomal drug delivery and sustained-release formulations enable prolonged anesthetic duration and reduced systemic toxicity that improve patient safety while extending pain-free periods post-procedure.
Market restraints include systemic toxicity concerns and cardiovascular effects at high doses that can challenge clinical adoption in certain patient populations, particularly in regions where advanced monitoring capabilities prove limited and emergency management protocols remain underdeveloped.
Allergic reaction potential with ester-type local anesthetics poses another significant challenge, as clinical practice depends on careful patient screening and alternative agent availability, potentially restricting formulary options in allergy-sensitive populations. Competition from alternative pain management approaches including regional anesthesia techniques and multimodal analgesia protocols creates additional complexity for traditional local anesthetic positioning, demanding continuous clinical evidence generation and safety profile optimization.
Key trends indicate accelerated adoption of long-acting formulations in developed markets, particularly North America and Europe, where clinicians demonstrate preference for extended-duration products reducing post-operative opioid requirements and enabling enhanced recovery protocols.
Liposomal bupivacaine innovation trends toward single-injection prolonged analgesia with 72-hour pain control duration enable improved patient outcomes and reduced hospital length of stay supporting value-based care objectives. The market could face disruption if significant advances in non-pharmacological pain management technologies or major regulatory restrictions on local anesthetic use in certain settings reduce reliance on traditional local anesthesia drug products.
Analysis of the Local Anesthesia Drugs Market by Key Countries

| Country | CAGR (2025 to 2035) |
|---|---|
| India | 11.1% |
| China | 10.4% |
| Brazil | 9.2% |
| usa | 8.7% |
| Saudi Arabia | 8.1% |
| Japan | 7.9% |
| Germany | 6.8% |
The global local anesthesia drugs market is expanding steadily, with India leading at a 11.1% CAGR through 2035, driven by rapid healthcare infrastructure expansion, growing outpatient procedure volumes, and increasing dental care accessibility supporting local anesthesia drug demand growth.
China follows at 10.4%, supported by cosmetic surgery market expansion, dental care modernization, and rising surgical procedure adoption. Brazil records 9.2%, reflecting strong cosmetic surgery sector growth and expanding private healthcare infrastructure.
usa grows at 8.7%, anchored by advanced surgical techniques and extensive ambulatory surgery center networks. Saudi Arabia advances at 8.1%, leveraging healthcare modernization programs and medical tourism development. Japan posts 7.9%, focusing on aging population surgical requirements, while Germany grows steadily at 6.8%, emphasizing orthopedic and dental procedure excellence.
How is India Leading Global Market Expansion?
India demonstrates the strongest growth potential in the local anesthesia drugs market with a CAGR of 11.1% through 2035. The country's leadership position stems from rapidly expanding healthcare infrastructure, growing middle-class access to dental and surgical care, and increasing adoption of outpatient procedures driving anesthetic drug consumption.
Growth is concentrated in major metropolitan areas and tier-2 cities, including Mumbai, Delhi, Bangalore, and Hyderabad, where patients are accessing modern surgical facilities and comprehensive dental services requiring reliable local anesthesia administration.
Distribution channels through hospital pharmacies and dental supply networks expand drug accessibility across surgical centers and dental clinics. The country's strong emphasis on healthcare accessibility improvement and dental care expansion provides robust momentum for local anesthesia drug adoption, including comprehensive implementation across clinical specialties.
Key market factors:
- Urban healthcare facility concentration in metropolitan areas and medical tourism hubs with rising procedure volumes
- Dental care expansion through private dental chains and standalone clinics enabling increased local anesthesia utilization
- Comprehensive pharmaceutical distribution ecosystem, including established hospital supply chains with proven quality standards
- Local manufacturing capabilities featuring generic drug production supporting cost-effective market access
Why is China Emerging as a High-Growth Market?
In major urban centers including Beijing, Shanghai, Guangzhou, and Shenzhen, the adoption of advanced local anesthesia products is accelerating across cosmetic surgery clinics and modern dental facilities, driven by rising disposable incomes and aesthetic procedure demand. The market demonstrates strong growth momentum with a CAGR of 10.4% through 2035, linked to comprehensive cosmetic surgery market expansion and increasing focus on dental aesthetics and preventive dental care.
Chinese patients are accessing elective procedures and quality dental interventions requiring safe local anesthetic administration to enhance appearance and maintain oral health standards. The country's massive population base creates ongoing demand for dental restorative procedures, while expanding cosmetic surgery acceptance drives adoption of local anesthesia for minimally invasive aesthetic treatments.
Key development areas:
- Cosmetic surgery clinics and dental facilities leading local anesthesia drug adoption with emphasis on patient safety
- Healthcare facility modernization through private hospital expansion and specialty clinic development enabling quality care delivery
- Regulatory improvements enabling faster drug approval and quality standard enforcement in pharmaceutical manufacturing
- Growing preference for branded pharmaceutical products alongside competitive generic alternatives in clinical settings
What drives USA’s Market Resilience?

usa’s market expansion is driven by diverse surgical applications, including ambulatory surgery center procedures and dental practice interventions across established healthcare infrastructure. The country demonstrates steady growth potential with a CAGR of 8.7% through 2035, supported by continuous product innovation from major manufacturers including Johnson & Johnson Services, Inc. and Pfizer Inc.
American healthcare providers face implementation challenges related to opioid crisis responses and multimodal pain management requirements, necessitating increased reliance on regional anesthesia and local anesthetic techniques for post-operative pain control. However, established surgical volumes and comprehensive dental care access create stable baseline demand for local anesthesia drugs, particularly in outpatient applications where same-day discharge protocols drive anesthetic selection decisions.
Market characteristics:
- Ambulatory surgery and dental practice segments showing robust demand with substantial annual procedure volumes
- Regional anesthesia technique adoption in orthopedic and obstetric settings driving long-acting formulation utilization
- Future projections indicate continued advanced formulation development with emphasis on extended-duration products
- Growing emphasis on opioid-sparing analgesia strategies supporting increased local anesthetic utilization in surgical protocols
What Positions Brazil for Cosmetic Surgery Leadership?
The market in Brazil demonstrates strong cosmetic procedure demand based on cultural emphasis on aesthetic appearance and established cosmetic surgery industry for body contouring and facial rejuvenation. The country shows robust potential with a CAGR of 9.2% through 2035, driven by high cosmetic surgery volumes and aesthetic procedure accessibility in major markets, including São Paulo, Rio de Janeiro, Brasília, and Belo Horizonte.
Brazilian practitioners are utilizing local anesthesia formulations for tumescent liposuction, facial filler procedures, and minimally invasive cosmetic interventions supporting beauty standard maintenance, particularly in urban populations demanding comprehensive aesthetic treatment options. Distribution channels through specialized aesthetic clinics and private surgical facilities expand coverage across appearance-conscious patient demographics.
Leading market segments:
- Cosmetic surgery clinics in major urban centers implementing local anesthesia for outpatient aesthetic procedures
- Dental practice expansion driving local anesthetic consumption for restorative and cosmetic dental interventions
- Strategic distribution through pharmaceutical wholesalers and specialty medical supply companies expanding market reach
- Focus on affordable cosmetic procedures enabling middle-class access to aesthetic treatments requiring local anesthesia
How does Saudi Arabia Demonstrate Healthcare Modernization Leadership?
The market in Saudi Arabia leads in healthcare infrastructure development based on government investment in medical facility expansion and medical tourism promotion for specialized care delivery. The country shows strong potential with a CAGR of 8.1% through 2035, driven by Vision 2030 healthcare initiatives and comprehensive facility modernization in major cities, including Riyadh, Jeddah, Dammam, and Makkah.
Healthcare providers are adopting international-standard local anesthesia protocols and modern surgical techniques for quality improvement, particularly in specialty hospitals and private medical centers demanding comprehensive pharmaceutical supply. Distribution channels through centralized hospital procurement and specialty pharmaceutical distributors expand coverage across modern healthcare facilities.
Key development areas:
- Hospital systems in major cities implementing advanced surgical protocols requiring reliable local anesthesia supplies
- Medical tourism development providing growth opportunities in specialty surgical and dental care delivery
- Pharmaceutical supply chain modernization enabling quality assurance and temperature-controlled distribution networks
- Growing private healthcare sector driving demand for premium pharmaceutical products with established safety profiles
What positions Japan for Aging Population Care Leadership?

In Tokyo, Osaka, Nagoya, and other major cities, healthcare facilities are implementing local anesthesia products for elderly patient procedures featuring minimally invasive techniques and outpatient management approaches, with documented case studies showing substantial safety improvements through careful patient selection and monitoring protocols. The market shows steady growth potential with a CAGR of 7.9% through 2035, linked to ongoing demographic aging, emphasis on quality-of-life procedures, and emerging dental care requirements in elderly populations.
Japanese practitioners are adopting careful anesthetic dosing and advanced monitoring for geriatric patients requiring cataract surgery, dental procedures, and dermatological interventions to maintain functional independence while managing age-related healthcare needs. The country's established universal healthcare system creates ongoing demand for cost-effective local anesthesia solutions supporting outpatient procedure delivery.
Market development factors:
- Elderly patient populations leading procedure volumes requiring careful local anesthesia management across Japan
- Quality healthcare delivery emphasizing patient safety protocols and comprehensive monitoring standards
- Technology collaboration between Japanese medical device companies and pharmaceutical manufacturers expanding integrated solutions
- Emphasis on dental care maintenance in aging populations addressing tooth preservation and oral health requirements
How does Germany Show Surgical Excellence?
The German market demonstrates advanced surgical techniques and comprehensive pain management based on integration with evidence-based anesthesia protocols and quality clinical practice standards. The country shows steady potential with a CAGR of 6.8% through 2035, driven by high orthopedic procedure volumes and dental care excellence in major regions, including Bavaria, North Rhine-Westphalia, Baden-Württemberg, and Lower Saxony.
German practitioners are utilizing local anesthesia formulations for joint replacement procedures, sports medicine interventions, and comprehensive dental restorations supporting active lifestyle maintenance, particularly in health-conscious populations demanding comprehensive surgical care options. Distribution channels through hospital pharmacies and dental supply specialists expand coverage across quality-focused healthcare providers.
Key development areas:
- Orthopedic surgery centers in major cities implementing regional anesthesia techniques for joint replacement procedures
- Dental practice excellence driving local anesthetic consumption for complex restorative and surgical dental interventions
- Pharmaceutical quality standards ensuring product consistency and safety compliance across clinical applications
- Healthcare professional training emphasis supporting proper anesthetic technique and patient safety protocols
Europe Market Split by Country

The local anesthesia drugs market in Europe is projected to grow from USD 1.1 billion in 2025 to USD 2.3 billion by 2035, registering a CAGR of 7.7% over the forecast period. Germany is expected to maintain its leadership position with a 24.6% market share in 2025, adjusting slightly to 24.2% by 2035, supported by its advanced surgical infrastructure, comprehensive dental care networks, and stringent pharmaceutical quality standards serving major European markets.
France follows with a 19.8% share in 2025, projected to reach 20.1% by 2035, driven by comprehensive surgical procedure volumes and aesthetic medicine growth in major regions. UK holds a 18.4% share in 2025, expected to maintain 18.6% by 2035 through ongoing development of ambulatory surgery centers and dental practice expansion.
Italy commands a 15.7% share, while Spain accounts for 13.2% in 2025. The rest of Europe region is anticipated to gain momentum, expanding its collective share from 8.3% to 8.9% by 2035, attributed to increasing local anesthesia drug adoption in Nordic countries and emerging Eastern European healthcare facilities implementing surgical service development programs.
Competitive Landscape of the Local Anesthesia Drugs Market

The local anesthesia drugs market features approximately 15-20 meaningful players with moderate concentration, where the top three companies control roughly 28-35% of global market share through established pharmaceutical portfolios and extensive clinical evidence bases.
Competition centers on product safety profiles, clinical efficacy data, and regulatory compliance rather than price competition alone. Market leaders include Johnson & Johnson Services, Inc., Pfizer Inc., and AstraZeneca plc, which maintain competitive advantages through comprehensive local anesthesia drug portfolios, extensive clinical trial programs, and deep expertise in pharmaceutical development, creating strong prescriber loyalty among clinicians.
These companies leverage established hospital relationships and ongoing formulation innovation initiatives to defend market positions while expanding into adjacent categories including extended-release formulations and combination products.
Challengers encompass Novartis AG and Teva Pharmaceutical Industries Ltd., which compete through specialized product offerings and strong market presence in key regional territories. Pharmaceutical specialists, including GSK plc, Sanofi S.A., and Merck & Co., Inc., focus on specific therapeutic segments or geographic markets, offering differentiated capabilities in branded formulations, generic alternatives, and specialty anesthetic products.
Regional players and emerging generic manufacturers create competitive pressure through cost-effective drug offerings and localized market access, particularly in high-growth markets including India and China, where generic competition provides advantages in pricing structures and healthcare system affordability requirements.
Market dynamics favor companies that combine proven drug safety with comprehensive clinical support that addresses the complete value chain from pharmaceutical development through medical education and adverse event monitoring. Strategic emphasis on extended-duration formulations, reduced toxicity profiles, and combination product development enables differentiation in increasingly safety-conscious clinical environments across developed and emerging markets.
Global Local Anesthesia Drugs Market - Stakeholder Contribution Framework
Local anesthesia drugs represent critical pharmaceutical products that enable healthcare providers to maintain superior patient comfort and procedural safety without complex anesthetic management requirements, typically providing targeted pain control and rapid recovery compared to general anesthesia alternatives while ensuring effective nerve blockade and consistent clinical outcomes.
With the market projected to grow from USD 4.3 billion in 2025 to USD 10.5 billion by 2035 at a 9.3% CAGR, these drugs offer compelling advantages - superior safety profiles, rapid onset characteristics, and versatile application capabilities - making them essential for surgical procedures, dental interventions, and diverse clinical segments seeking reliable pain management solutions. Scaling market penetration and safe utilization requires coordinated action across regulatory frameworks, clinical training programs, pharmaceutical manufacturers, healthcare providers, and pharmacovigilance initiatives.
How Could Governments Spur Local Development and Adoption?
- Healthcare Access Programs: Include surgical and dental care expansion in national health strategies, providing targeted support for ambulatory surgery center development and supporting local pharmaceutical manufacturers through quality assurance programs.
- Tax Policy & Investment Support: Implement reduced import duties for essential anesthetic drugs, provide tax incentives for companies investing in pharmaceutical manufacturing capacity and quality control systems, and establish favorable pricing policies that balance patient access with innovation incentives.
- Regulatory Framework Development: Create streamlined approval processes for generic local anesthetic formulations, establish clear bioequivalence standards and quality requirements for pharmaceutical manufacturing, and develop adverse event monitoring systems that ensure patient safety.
- Skills Development & Training: Fund medical education programs for anesthesiologists, surgeons, and dental practitioners. Invest in clinical training initiatives that bridge pharmacological knowledge with safe administration techniques and toxicity management protocols.
- Market Access & Competition: Establish essential medicines lists including core local anesthetic agents, support generic pharmaceutical development through regulatory guidance and technical assistance, and create procurement frameworks that ensure drug availability across public healthcare facilities.
How Could Industry Bodies Support Market Development?
- Clinical Standards & Guidelines: Define standardized dosing protocols for local anesthesia drugs across surgical, dental, and procedural applications, establish universal safety monitoring and toxicity management guidelines, and create certification programs for clinical competency that healthcare providers can pursue.
- Market Education & Best Practices: Lead messaging that demonstrates local anesthesia advantages, emphasizing superior safety profiles, rapid recovery characteristics, and cost-effectiveness compared to general anesthesia for appropriate procedures.
- Pharmacovigilance Standards: Develop guidelines for adverse event reporting, systemic toxicity recognition, and emergency management protocols, ensuring consistent safety monitoring across clinical practice settings.
- Professional Development: Run certification programs for anesthesia providers, surgical teams, and dental practitioners on optimizing drug selection, proper administration techniques, and patient safety management in diverse clinical environments.
How Could Manufacturers and Technology Players Strengthen the Ecosystem?
- Advanced Formulation Development: Develop next-generation local anesthesia drugs with enhanced duration profiles, reduced systemic toxicity, and application-specific characteristics that improve clinical outcomes while minimizing adverse effects.
- Drug Delivery Innovation: Provide advanced delivery systems, sustained-release technologies, and combination formulations that maximize efficacy and support optimal pain control across procedural applications.
- Clinical Education Programs: Offer comprehensive training about proper drug selection, dosing calculations, and toxicity recognition that help healthcare providers maximize patient safety aligned with clinical requirements.
- Research & Development Networks: Build comprehensive R&D capabilities, collaborative clinical trial programs, and post-market surveillance systems that ensure local anesthesia drugs maintain high safety standards and consistent efficacy across diverse patient populations.
How Could Healthcare Providers and Distributors Navigate the Market?
- Diversified Product Portfolios: Expand local anesthesia drug offerings across amide agents, ester alternatives, and specialized formulations, with particular focus on long-acting products and combination preparations for enhanced clinical utility.
- Geographic Market Development: Establish operations in high-growth markets like India and China, while strengthening presence in established markets like USA and Germany through optimized pharmaceutical distribution and clinical support programs.
- Clinical Support Integration: Implement comprehensive medical education, adverse event monitoring, and clinical consultation services that differentiate pharmaceutical offerings and improve prescriber confidence.
- Quality Assurance Excellence: Develop rigorous quality control programs and supply chain integrity systems ensuring product authenticity and temperature-controlled distribution for pharmaceutical stability.
How Could Investors and Financial Enablers Unlock Value?
- Manufacturing Capacity Financing: Provide growth capital for established companies like Johnson & Johnson Services, Inc., Pfizer Inc., and Novartis AG to expand production facilities and quality systems, particularly in emerging markets with growing pharmaceutical demands.
- Innovation Investment: Back companies developing advanced formulations, extended-release technologies, and novel local anesthetic molecules that enhance clinical performance and patient safety.
- Regional Expansion Funding: Finance market entry and distribution network expansion strategies for pharmaceutical companies establishing operations in high-growth regions, supporting regulatory approval processes and market access initiatives.
- Consolidation & Scale Opportunities: Support strategic acquisitions and market consolidation that create manufacturing scale advantages, improve research capabilities, and enhance competitive positioning against generic competition across multiple geographic markets.
Key Players in the Local Anesthesia Drugs Market
- Johnson & Johnson Services, Inc.
- Pfizer Inc.
- AstraZeneca plc
- Novartis AG
- Teva Pharmaceutical Industries Ltd.
- GSK plc
- Sanofi S.A.
- Merck & Co., Inc.
- Aspen Holdings
- Viatris Inc.
Scope of the Report
| Items | Values |
|---|---|
| Quantitative Units | USD 4.3 Billion |
| Drug Type | Lidocaine, Bupivacaine, Ropivacaine, Chloroprocaine, Prilocaine, Benzocaine, Others |
| Application | Injectable, Surface Anesthetic |
| Regions Covered | Asia Pacific, Europe, North America, Latin America, mea |
| Country Covered | India, China, USA, Germany, Japan, Brazil, Saudi Arabia, and 40+ countries |
| Key Companies Profiled | Johnson & Johnson Services, Inc., Pfizer Inc., AstraZeneca plc, Novartis AG, Teva Pharmaceutical Industries Ltd., GSK plc, Sanofi S.A., Merck & Co., Inc., Aspen Holdings, Viatris Inc. |
| Additional Attributes | Dollar sales by drug type and application categories, regional adoption trends across Asia Pacific, Europe, and North America, competitive landscape with pharmaceutical manufacturers and healthcare providers, drug specifications and safety profiles, integration with surgical protocols and dental practice standards, innovations in extended-release formulations and combination products, and development of specialized applications with reduced toxicity and enhanced duration capabilities. |
Local Anesthesia Drugs Market by Segments
-
Drug Type :
- Lidocaine
- Bupivacaine
- Ropivacaine
- Chloroprocaine
- Prilocaine
- Benzocaine
- Others
-
Application :
- Injectable
- Surface Anesthetic
-
Region :
- Asia Pacific
- China
- Japan
- South Korea
- India
- Australia & New Zealand
- ASEAN
- Rest of Asia Pacific
- Europe
- Germany
- UK
- France
- Italy
- Spain
- Nordic
- BENELUX
- Rest of Europe
- North America
- usa
- Canada
- Mexico
- Latin America
- Brazil
- Chile
- Rest of Latin America
- mea
- Kingdom of Saudi Arabia
- Other GCC Countries
- Turkey
- South Africa
- Other African Union
- Rest of mea
- Asia Pacific
Table of Content
- Executive Summary
- Global Market Outlook
- Demand to side Trends
- Supply to side Trends
- Technology Roadmap Analysis
- Analysis and Recommendations
- Market Overview
- Market Coverage / Taxonomy
- Market Definition / Scope / Limitations
- Market Background
- Market Dynamics
- Drivers
- Restraints
- Opportunity
- Trends
- Scenario Forecast
- Demand in Optimistic Scenario
- Demand in Likely Scenario
- Demand in Conservative Scenario
- Opportunity Map Analysis
- Product Life Cycle Analysis
- Supply Chain Analysis
- Investment Feasibility Matrix
- Value Chain Analysis
- PESTLE and Porter’s Analysis
- Regulatory Landscape
- Regional Parent Market Outlook
- Production and Consumption Statistics
- Import and Export Statistics
- Market Dynamics
- Global Market Analysis 2020 to 2024 and Forecast, 2025 to 2035
- Historical Market Size Value (USD Million) Analysis, 2020 to 2024
- Current and Future Market Size Value (USD Million) Projections, 2025 to 2035
- Y to o to Y Growth Trend Analysis
- Absolute $ Opportunity Analysis
- Global Market Pricing Analysis 2020 to 2024 and Forecast 2025 to 2035
- Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Drug Type
- Introduction / Key Findings
- Historical Market Size Value (USD Million) Analysis By Drug Type, 2020 to 2024
- Current and Future Market Size Value (USD Million) Analysis and Forecast By Drug Type, 2025 to 2035
- Lidocaine
- Bupivacaine
- Ropivacaine
- Chloroprocaine
- Prilocaine
- Benzocaine
- Others
- Y to o to Y Growth Trend Analysis By Drug Type, 2020 to 2024
- Absolute $ Opportunity Analysis By Drug Type, 2025 to 2035
- Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Application
- Introduction / Key Findings
- Historical Market Size Value (USD Million) Analysis By Application, 2020 to 2024
- Current and Future Market Size Value (USD Million) Analysis and Forecast By Application, 2025 to 2035
- Injectable
- Surface Anesthetic
- Y to o to Y Growth Trend Analysis By Application, 2020 to 2024
- Absolute $ Opportunity Analysis By Application, 2025 to 2035
- Global Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Region
- Introduction
- Historical Market Size Value (USD Million) Analysis By Region, 2020 to 2024
- Current Market Size Value (USD Million) Analysis and Forecast By Region, 2025 to 2035
- North America
- Latin America
- Western Europe
- Eastern Europe
- East Asia
- South Asia and Pacific
- Middle East & Africa
- Market Attractiveness Analysis By Region
- North America Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- USA
- Canada
- Mexico
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- Latin America Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- Brazil
- Chile
- Rest of Latin America
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- Western Europe Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- Germany
- UK
- Italy
- Spain
- France
- Nordic
- BENELUX
- Rest of Western Europe
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- Eastern Europe Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- Russia
- Poland
- Hungary
- Balkan & Baltic
- Rest of Eastern Europe
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- East Asia Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- China
- Japan
- South Korea
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- South Asia and Pacific Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- India
- ASEAN
- Australia & New Zealand
- Rest of South Asia and Pacific
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- Middle East & Africa Market Analysis 2020 to 2024 and Forecast 2025 to 2035, By Country
- Historical Market Size Value (USD Million) Trend Analysis By Market Taxonomy, 2020 to 2024
- Market Size Value (USD Million) Forecast By Market Taxonomy, 2025 to 2035
- By Country
- Kingdom of Saudi Arabia
- Other GCC Countries
- Turkiye
- South Africa
- Other African Union
- Rest of Middle East & Africa
- By Drug Type
- By Application
- By Country
- Market Attractiveness Analysis
- By Country
- By Drug Type
- By Application
- Key Takeaways
- Key Countries Market Analysis
- USA
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Canada
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Mexico
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Brazil
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Chile
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Germany
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- UK
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Italy
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Spain
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- France
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- India
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- ASEAN
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Australia & New Zealand
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- China
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Japan
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- South Korea
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Russia
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Poland
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Hungary
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Kingdom of Saudi Arabia
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- Turkiye
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- South Africa
- Pricing Analysis
- Market Share Analysis, 2024
- By Drug Type
- By Application
- USA
- Market Structure Analysis
- Competition Dashboard
- Competition Benchmarking
- Market Share Analysis of Top Players
- By Regional
- By Drug Type
- By Application
- Competition Analysis
- Competition Deep Dive
- Johnson & Johnson Services, Inc.
- Overview
- Product Portfolio
- Profitability by Market Segments (Product/Age /Sales Channel/Region)
- Sales Footprint
- Strategy Overview
- Marketing Strategy
- Product Strategy
- Channel Strategy
- Pfizer Inc.
- AstraZeneca plc
- Novartis AG
- Teva Pharmaceutical Industries Ltd.
- GSK plc
- Sanofi S.A.
- Merck & Co., Inc.
- Aspen Holdings
- Viatris Inc.
- Johnson & Johnson Services, Inc.
- Competition Deep Dive
- Assumptions & Acronyms Used
- Research Methodology
List Of Table
- Table 1: Global Market Value (USD Million) Forecast by Region, 2020 to 2035
- Table 2: Global Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 3: Global Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 4: North America Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 5: North America Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 6: North America Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 7: Latin America Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 8: Latin America Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 9: Latin America Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 10: Western Europe Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 11: Western Europe Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 12: Western Europe Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 13: Eastern Europe Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 14: Eastern Europe Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 15: Eastern Europe Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 16: East Asia Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 17: East Asia Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 18: East Asia Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 19: South Asia and Pacific Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 20: South Asia and Pacific Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 21: South Asia and Pacific Market Value (USD Million) Forecast by Application, 2020 to 2035
- Table 22: Middle East & Africa Market Value (USD Million) Forecast by Country, 2020 to 2035
- Table 23: Middle East & Africa Market Value (USD Million) Forecast by Drug Type, 2020 to 2035
- Table 24: Middle East & Africa Market Value (USD Million) Forecast by Application, 2020 to 2035
List Of Figures
- Figure 1: Global Market Pricing Analysis
- Figure 2: Global Market Value (USD Million) Forecast 2020 to 2035
- Figure 3: Global Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 4: Global Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 5: Global Market Attractiveness Analysis by Drug Type
- Figure 6: Global Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 7: Global Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 8: Global Market Attractiveness Analysis by Application
- Figure 9: Global Market Value (USD Million) Share and BPS Analysis by Region, 2025 and 2035
- Figure 10: Global Market Y to o to Y Growth Comparison by Region, 2025 to 2035
- Figure 11: Global Market Attractiveness Analysis by Region
- Figure 12: North America Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 13: Latin America Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 14: Western Europe Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 15: Eastern Europe Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 16: East Asia Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 17: South Asia and Pacific Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 18: Middle East & Africa Market Incremental Dollar Opportunity, 2025 to 2035
- Figure 19: North America Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 20: North America Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 21: North America Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 22: North America Market Attractiveness Analysis by Drug Type
- Figure 23: North America Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 24: North America Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 25: North America Market Attractiveness Analysis by Application
- Figure 26: Latin America Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 27: Latin America Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 28: Latin America Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 29: Latin America Market Attractiveness Analysis by Drug Type
- Figure 30: Latin America Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 31: Latin America Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 32: Latin America Market Attractiveness Analysis by Application
- Figure 33: Western Europe Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 34: Western Europe Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 35: Western Europe Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 36: Western Europe Market Attractiveness Analysis by Drug Type
- Figure 37: Western Europe Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 38: Western Europe Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 39: Western Europe Market Attractiveness Analysis by Application
- Figure 40: Eastern Europe Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 41: Eastern Europe Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 42: Eastern Europe Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 43: Eastern Europe Market Attractiveness Analysis by Drug Type
- Figure 44: Eastern Europe Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 45: Eastern Europe Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 46: Eastern Europe Market Attractiveness Analysis by Application
- Figure 47: East Asia Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 48: East Asia Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 49: East Asia Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 50: East Asia Market Attractiveness Analysis by Drug Type
- Figure 51: East Asia Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 52: East Asia Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 53: East Asia Market Attractiveness Analysis by Application
- Figure 54: South Asia and Pacific Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 55: South Asia and Pacific Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 56: South Asia and Pacific Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 57: South Asia and Pacific Market Attractiveness Analysis by Drug Type
- Figure 58: South Asia and Pacific Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 59: South Asia and Pacific Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 60: South Asia and Pacific Market Attractiveness Analysis by Application
- Figure 61: Middle East & Africa Market Value Share and BPS Analysis by Country, 2025 and 2035
- Figure 62: Middle East & Africa Market Value Share and BPS Analysis by Drug Type, 2025 and 2035
- Figure 63: Middle East & Africa Market Y to o to Y Growth Comparison by Drug Type, 2025 to 2035
- Figure 64: Middle East & Africa Market Attractiveness Analysis by Drug Type
- Figure 65: Middle East & Africa Market Value Share and BPS Analysis by Application, 2025 and 2035
- Figure 66: Middle East & Africa Market Y to o to Y Growth Comparison by Application, 2025 to 2035
- Figure 67: Middle East & Africa Market Attractiveness Analysis by Application
- Figure 68: Global Market - Tier Structure Analysis
- Figure 69: Global Market - Company Share Analysis
- FAQs -
How big is the local anesthesia drugs market in 2025?
The global local anesthesia drugs market is estimated to be valued at USD 4.3 billion in 2025.
What will be the size of local anesthesia drugs market in 2035?
The market size for the local anesthesia drugs market is projected to reach USD 10.5 billion by 2035.
How much will be the local anesthesia drugs market growth between 2025 and 2035?
The local anesthesia drugs market is expected to grow at a 9.3% CAGR between 2025 and 2035.
What are the key product types in the local anesthesia drugs market?
The key product types in local anesthesia drugs market are lidocaine, bupivacaine, ropivacaine, chloroprocaine, prilocaine, benzocaine and others.
Which application segment to contribute significant share in the local anesthesia drugs market in 2025?
In terms of application, injectable segment to command 59.8% share in the local anesthesia drugs market in 2025.