Lyophilization Market

Lyophilization Market Outlook (2024 to 2034)

The global lyophilization market size is calculated at US$ 1.14 billion for 2024 and has been analyzed to increase at a CAGR of 8.6% to reach a valuation of US$ 2.61 billion by 2034. Market growth is mainly attributed to rising demand for lyophilization technologies in biopharmaceutical companies.

Several benefits associated with the lyophilization process and technological advancements in freeze-drying equipment are major factors driving the lyophilization market growth. The lyophilization process is beneficial for extending the shelf life of pharmaceutical drugs and biopharmaceutical products such as antibodies, vaccines, peptides, and others.

The lyophilization process helps in the removal of moisture by putting the product under three interconnected steps - freezing, primary drying, and secondary drying. This not only helps in stabilizing pharmaceutical formulations but also broadens the capability of temperature tolerance in these products.

Since temperature is a crucial parameter for various pharmaceuticals and biopharmaceuticals, freeze dryers are developed that can easily optimize the shelf temperature and chamber pressure so that the quality of the product is not hampered while it is below its critical point. These freeze dryers maximize the sublimation rate as well, thereby enhancing the stability of compounds.

Increasing hectic lifestyles of consumers in North America are driving demand for freeze dried products such as cheese, meat, and more. This is subsequently driving the growth of the market for lyophilization.

• North America is expected to hold 35.8% of the global lyophilization market share by 2034.
• The East Asian lyophilization market size is evaluated at US$ 194.1 million in 2024.

Report Attributes	Details
Lyophilization Market Size (2024E)	US$ 1.14 Billion
Forecasted Market Value (2034F)	US$ 2.61 Billion
Global Market Growth Rate (2024 to 2034)	8.6% CAGR
South Korea Market Value (2034F)	US$ 94.6 Million
Key Companies Profiled	Cuddon Freeze Dry Neologic Engineers Private Limited Azbil Corporation MechaTech Systems Ltd. SP Industries, Inc. Labconco Corporation BÜCHI Labortechnik AG Cryotec.Fr Martin Christ Gefriertrocknungsanlagen GmbH Zirbus Technology GmbH HOF Sonderanlagenbau GmbH Lyophilization Systems Ltd. Freeze-drying Systems Pvt. Ltd. Yamato Scientific America Inc. Millrock Technology, Inc. IMA – Industria Macchine Automatiche S.p.A. GEA Group

Why are Lyophilization Technologies Gaining Traction?

“Investments in Research and Development to Offer Advanced Lyophilization Solutions”

Since there are some biopharmaceutical products that cannot be marketed without undergoing the lyophilization process, the need for investments in the research and development of lyophilization is rising day by day. The integration of advanced technologies to increase the scalability and quality of end products is one of the notable lyophilization market trends.

• Lyophilization technology hub (LyoHUB) aims at advancing science and technology focusing on freeze-drying or lyophilization.

Some of the manufacturers are even partnering with this hub to focus on advancements in lyophilization techniques. The growing attention towards advancements in lyophilization products and processes is further boosting the growth of the overall lyophilization market.

“Rising Demand for Lyophilization Services across Regions”

Increasing demand for lyophilization services is creating greater opportunities for the manufacturers of freeze dryers and their accessories. Different organizations offer services for successful pharmaceutical drug development and manufacturing processes. These include contract development and manufacturing organizations (CDMOs) and contract manufacturing organizations (CMOs).

• For instance, LSNE Contract Manufacturing is a CMO that helps various pharmaceutical companies produce commercial products. It offers manufacturing services that comprise aseptic fill-finish manufacturing and lyophilization, bulk lyophilization, non-aseptic fill-finish & lyophilization, and others.

What’s Restraining Widespread Adoption of Lyophilization Solutions?

“High Costs Associated with Lyophilization Setup”

Cost of freeze-drying equipment is quite high, and this restricts small- and medium-scale companies from acquiring such equipment to carry out the lyophilization process. Thus, high costs associated with lyophilization setup are majorly hampering its demand growth.

What is Set to Push Profits of New Companies?

“Introduction of Advanced Lyophilization Technologies to Attract Wider Consumer Base”

Start-ups should focus on the production of single use technologies in operations where sterility is important. Single use technologies automate the fill and finish process to speed it up and reduce the variability chances associated with manual processing.

• CMAB Biopharma a Chinese start-up offers solutions for filling and lyophilization and also process development of good manufacturing practice.
• Zip Diagnostics is an Australian start-up that focuses on infectious diseases and offers point-of-care tests. These systems optimize the lyophilization processes to boost the stability of assay chemistry.

Country-wise Analysis

Fact.MR, a market research and competitive intelligence provider estimated that in the North American market, the United States is estimated to hold 88.2% market share in 2024. This can be attributed to the strong presence of key market players and end users.

What is the United States Market Stance for Lyophilization?

“Ever-increasing Consumption of Freeze-dried Food Products”

Attribute	United States
Market Value (2024E)	US$ 355.2 Million
Growth Rate (2024 to 2034)	10.1% CAGR
Projected Value (2034F)	US$ 933.2 Million

The United States is witnessing increasing demand for lyophilization solutions owing to the trend of the general population preferring freeze-dried food products and an increase in the number of organizations offering lyophilization services, as enlisted by the FDA.

Increasing consumption of freeze-dried vegetables, fruits, and food are driving the demand for lyophilizers in the food processing industry. It provides stability to food products, thereby increasing their shelf life.

• Jubilant HollisterStier is a contract manufacturing organization in the United States that offers specialized facilities for lyophilization. It is focusing on investing in new lyophilizers to broaden its portfolio.

Will Germany Be a Lucrative Market for Lyophilization Providers?

“F&B Industry Major Consumer of Lyophilization Solutions”

• As per the Germany Trade and Invest (the economic development agency of the Federal Republic of Germany), the industry of food and beverages in Germany is the largest in the European region.

Expanding German food industry is demanding lyophilization techniques so that companies can provide high-quality freeze-dried products effectively. Lyophilization not only increases the shelf life of food products but also facilitates easier and more convenient storage. This leverages the logistics of these food industries, thereby making Germany’s food and beverage industry a top contender in the European region.

Presence of various manufacturers further increases the availability of freeze dryers and their accessories in Germany. Manufacturers such as Zirbus Technology GmbH, HOF Sonderanlagenbau GmbH, Martin Christ Gefriertrocknungsanlagen GmbH and GEA Group have their head offices in country.

What Makes China a Key Market for Lyophilization Solution Providers in East Asia?

“Pharmaceutical Companies Widely Utilizing Lyophilizers and Freeze Dryers as Stability Tools”

Attribute	China
Market Value (2024E)	US$ 86.2 Million
Growth Rate (2024 to 2034)	11.9% CAGR
Projected Value (2034F)	US$ 264.2 Million

Increasing awareness about the advantages of lyophilized products is aiding in sales growth of lyophilizers and freeze dryers in China. The growing number of domestic pharmaceutical companies is further boosting the lyophilization market growth within the country because lyophilization acts as a stability tool for the pharmaceutical and food processing industries.

Category-wise Analysis

Industrial-scale freeze drying process requires high automation to put up high production volumes and to ensure consistency in every batch. This is increasing their demand in large scale enterprises for stabilization and preservation of large volume products.

Which Scale of Operation is Boosting Demand Growth for Lyophilization?

“Surge in Industrial-Scale Operations Driving Demand for Lyophilization Solutions”

Attribute	Industrial-Scale
Segment Value (2024E)	US$ 514 Million
Growth Rate (2024 to 2034)	8.2% CAGR
Projected Value (2034F)	US$ 1.12 Billion

Industrial-scale operations are the biggest platform where freeze-drying equipment is utilized for lyophilization purposes. Manufacturing is done at the industrial level; therefore, demand for industrial freeze dryers is more at the large scale of operations. Industrial-scale freeze drying equipment are typically installed in large food processing, pharma, and biotech companies to increase the shell life of end products.

What is Driving Demand for Tray-Style Freeze Dryers?

“Tray-Style Freeze Dryers Exhibiting Increasing Demand from Pharma and Food Processing Companies”

Attribute	Tray-Style Freeze Dryers
Segment Value (2024E)	US$ 698.4 Million
Growth Rate (2024 to 2034)	8.2% CAGR
Projected Value (2034F)	US$ 1.61 Billion

Freeze dryers, particularly tray-style dryers, are gaining traction across the globe. This high traction is being influenced by increasing research & development activities in lyophilization techniques. Furthermore, the advantages offered by lyophilizers and freeze dryers are profitable for researchers in pharmaceutical, biopharmaceutical, and food processing industries. This is expected to boost the sales of freeze dryers in the coming decade.

Competitive Landscape

Key manufacturers of lyophilizers and their accessories are actively focusing on the expansion of their businesses across various locations in the world. Key players in the lyophilization market are also focusing on innovation by launching new products as a strategy to boost their position. Apart from this, collaborations and partnerships are a major promotional strategy carried out by different industry players.

• In June 2021, SP Industries Inc. launched the SP Hull LyoStar® 4.0 R&D freeze dryer to support freeze-dry cycle development, optimization, and process scale-up.
• In April 2022, Azbil expanded its operations by opening a new factory in China, through its production base in China called Azbil Control Instruments (Dalian) Co., Ltd.

Key Segments of Lyophilization Market Research

• By Product :

  • Tray-style Dryers
  • Rotary Freeze Dryers
  • Manifold Freeze Dryers

• By Scale of Operation :

  • Pilot-scale
  • Laboratory-scale
  • Industrial-scale

• By Accessories :

  • Loading & Unloading Systems
  • Control & Monitoring Systems
  • Vacuum Systems
  • CIP (Clean-in-place) Systems
  • Drying Chamber
  • Others

• By End User :

  • Biopharmaceutical Companies
  • Food & Beverage Companies
  • Academic & Research Institutes
  • CROs & CMOs
  • Hospitals
  • Research Laboratories

• By Region :

  • North America
  • Latin America
  • Europe
  • East Asia
  • South Asia & Oceania
  • Middle East & Africa